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Horizontal Cells, the Odd Ones Out in the Retina, Give Insights into Development and Disease
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
2016 (English)In: Frontiers in Neuroanatomy, ISSN 1662-5129, E-ISSN 1662-5129, Vol. 10, 77Article, review/survey (Refereed) PublishedText
Abstract [en]

Thorough investigation of a neuronal population can help reveal key aspects regarding the nervous system and its development. The retinal horizontal cells have several extraordinary features making them particularly interesting for addressing questions regarding fate assignment and subtype specification. In this review we discuss and summarize data concerning the formation and diversity of horizontal cells, how morphology is correlated to molecular markers, and how fate assignment separates the horizontal lineage from the lineages of other retinal cell types. We discuss the novel and unique features of the final cell cycle of horizontal cell progenitors and how they may relate to retinoblastoma carcinogenesis.

Place, publisher, year, edition, pages
2016. Vol. 10, 77
Keyword [en]
cell fate, cell cycle regulation, chicken, development, DNA damage, neuronal subtype, retinoblastoma, zebrafish
National Category
Neurology
Identifiers
URN: urn:nbn:se:uu:diva-301132DOI: 10.3389/fnana.2016.00077ISI: 000379879400001OAI: oai:DiVA.org:uu-301132DiVA: diva2:954455
Funder
Swedish Research Council
Available from: 2016-08-22 Created: 2016-08-18 Last updated: 2016-08-22Bibliographically approved

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Boije, HenrikFard, Shahrzad ShiraziEdqvist, Per-HenrikHallböök, Finn
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Department of NeuroscienceDepartment of Immunology, Genetics and Pathology
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