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Differences in cardiovascular toxicities associated with cigarette smoking and snuff use revealed using novel zebrafish models
Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Management and Engineering, Applied Thermodynamics and Fluid Mechanics. Linköping University, Faculty of Science & Engineering. Linköping University, Center for Medical Image Science and Visualization (CMIV).ORCID iD: 0000-0001-5526-2399
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2016 (English)In: Biology Open, ISSN 2046-6390, Vol. 5, no 7, 970-978 p.Article in journal (Refereed) Published
Abstract [en]

Tobacco use is strongly associated with cardiovascular disease and the only avoidable risk factor associated with development of aortic aneurysm. While smoking is the most common form of tobacco use, snuff and other oral tobacco products are gaining popularity, but research on potentially toxic effects of oral tobacco use has not kept pace with the increase in its use. Here, we demonstrate that cigarette smoke and snuff extracts are highly toxic to developing zebrafish embryos. Exposure to such extracts led to a palette of toxic effects including early embryonic mortality, developmental delay, cerebral hemorrhages, defects in lymphatics development and ventricular function, and aneurysm development. Both cigarette smoke and snuff were more toxic than pure nicotine, indicating that other compounds in these products are also associated with toxicity. While some toxicities were found following exposure to both types of tobacco product, other toxicities, including developmental delay and aneurysm development, were specifically observed in the snuff extract group, whereas cerebral hemorrhages were only found in the group exposed to cigarette smoke extract. These findings deepen our understanding of the pathogenic effects of cigarette smoking and snuff use on the cardiovascular system and illustrate the benefits of using zebrafish to study mechanisms involved in aneurysm development.

Place, publisher, year, edition, pages
Company of Biologists , 2016. Vol. 5, no 7, 970-978 p.
Keyword [en]
Aneurysm; Aorta; Cardiovascular; Snuff; Tobacco; Zebrafish
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
URN: urn:nbn:se:liu:diva-130706DOI: 10.1242/bio.018812ISI: 000380569100010PubMedID: 27334697OAI: oai:DiVA.org:liu-130706DiVA: diva2:954197
Note

The Jensen laboratory is supported by grants from Svenska Sallskapet for Medicinsk Forskning [grant F14-0021], Linkopings Universitet, Eva och Oscar Ahrens Stiftelse, Ollie och Elof Ericssons Stiftelse, Carmen och Bertil Ragners Stiftelse, Gosta Fraenkels Stiftelse, Ake Wibergs Stiftelse, Lions Forskningsfond, Karin Sandbergs Stiftelse, Cancerfonden, Karolinska Institutet's Stiftelser och Fonder and Vetenskapsradet [grant 2015-06271].

Available from: 2016-08-21 Created: 2016-08-21 Last updated: 2016-09-19

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Folkesson, MaggieSadowska, NataliaVikingsson, SvanteKarlsson, MattsCarlhäll, Carl-JohanLänne, TosteWågsäter, DickJensen, Lasse
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Division of Drug ResearchFaculty of Medicine and Health SciencesDivision of Cardiovascular MedicineApplied Thermodynamics and Fluid MechanicsFaculty of Science & EngineeringCenter for Medical Image Science and Visualization (CMIV)Department of Clinical Physiology in LinköpingDepartment of Thoracic and Vascular SurgeryDepartment of Clinical Pharmacology
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)

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