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Routine Development for Artefact Correction and Information Extraction from Diffusion Weighted Echo Planar Images of Rats
KTH, School of Technology and Health (STH).
2016 (English)Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesisAlternative title
Rutinutveckling för Artefaktkorrigering och Informationsextrahering från Diffusionsviktade Eko-Plana bilder av Råtta (Swedish)
Abstract [en]

Biologists and physicians study complex biologic phenomena in which they use advanced imaging methods. They acquire images containing a lot of information which must be extracted in a correct way. This requires computer skills and knowledge in image processing methods which they seldom have. To overcome the problem, this master thesis aimed to develop a routine for artefact correction and information extraction from images acquired in a research project at the Karolinska Institutet in Stockholm. By developing the routine, the thesis showed how software developed for images of human can be applied to images of rats. The routine handles formatting issues and artefact corrections, calculates diffusion metrics, and performs statistical tests on spatially aligned magnetic resonance images of rats acquired with diffusion weighted echo planar imaging. The routine was verified by analysing the images that it had processed and was considered to create reliable images. Future studies within the field should focus on developing atlases of rats and continue the work with identifying how software developed for images of human can be applied to images of rats. 

Abstract [sv]

Biologer och läkare studerar komplexa biologiska processer för vilket de använder avancerade bildgivande metoder. De samlar bilder som innehåller mycket information vilken måste extraheras på ett korrekt sätt. Detta kräver god datorvana och kunskaper inom bildprocessning, vilket de sällan har. För att komma runt problemet, syftade den här masteruppsattsen till att utveckla en rutin för artefaktkorrigering och informationsextrahering från bilder tagna i ett forskningsprojekt vid Karolinska Institutet i Stockholm. Genom att utveckla rutinen, visar uppsattsen hur mjukvaror utvecklade för bilder av människa kan appliceras på bilder av råtta. Rutinen hanterar formatteringsproblem och artefaktkorrigering, beräknar diffusionsmått, och utför statistiska tester på spatiellt matchade magnetresonansavbildningar tagna med diffusionsviktade ekoplana metoder. Rutinen verifierades genom att analysera bilder som den processat och det konstaterades att den skapar korrekta bilder. Framtida studier inom området bör fokusera på att utveckla atlaser av råttor och fortsätta identifieringen av hur mjukvaror utvecklade för bilder av människa kan appliceras på bilder av råtta. 

Place, publisher, year, edition, pages
2016. , 28 p.
Series
TRITA-STH, 2016:75
Keyword [en]
Image Processing, Rats, Routine, Artefact correction, Diffusion Weighted Imaging, Echo Planar Imaging
Keyword [sv]
Bildprocessning, Råtta, Rutin, Artefaktkorrigering, Diffusionsviktning, Eko-planarteknik
National Category
Medical Engineering
Identifiers
URN: urn:nbn:se:kth:diva-190993OAI: oai:DiVA.org:kth-190993DiVA: diva2:954131
External cooperation
Karolinska Experimental Research and Imaging Centre
Subject / course
Medical Engineering
Educational program
Master of Science in Engineering - Medical Engineering
Supervisors
Examiners
Available from: 2016-09-14 Created: 2016-08-20 Last updated: 2016-09-14Bibliographically approved

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