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Genome-wide association study identifies multiple susceptibility loci for multiple myeloma
Inst Canc Res, Div Genet & Epidemiol, 15 Cotswold Rd, Sutton SM2 5NG, Surrey, England..
Inst Canc Res, Div Genet & Epidemiol, 15 Cotswold Rd, Sutton SM2 5NG, Surrey, England..
Univ Arkansas Med Sci, Myeloma Inst Res & Therapy, Little Rock, AR 72205 USA.;Heidelberg Univ, Dept Internal Med, D-69117 Heidelberg, Germany..
German Canc Res Ctr, D-69120 Heidelberg, Germany.;Lund Univ, Ctr Primary Hlth Care Res, SE-20502 Malmo, Sweden..
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2016 (English)In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 7, article id 12050Article in journal (Refereed) Published
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Abstract [en]

Multiple myeloma (MM) is a plasma cell malignancy with a significant heritable basis. Genome-wide association studies have transformed our understanding of MM predisposition, but individual studies have had limited power to discover risk loci. Here we perform a meta-analysis of these GWAS, add a new GWAS and perform replication analyses resulting in 9,866 cases and 239,188 controls. We confirm all nine known risk loci and discover eight new loci at 6p22.3 (rs34229995, P = 1.31 x 10(-8)), 6q21 (rs9372120, P = 9.09 x 10(-15)), 7q36.1 (rs7781265, P = 9.71 x 10(-9)), 8q24.21 (rs1948915, P = 4.20 x 10(-11)), 9p21.3 (rs2811710, P = 1.72 x 10(-13)), 10p12.1 (rs2790457, P = 1.77 x 10(-8)), 16q23.1 (rs7193541, P = 5.00 x 10(-12)) and 20q13.13 (rs6066835, P = 1.36 x 10(-13)), which localize in or near to JARID2, ATG5, SMARCD3, CCAT1, CDKN2A, WAC, RFWD3 and PREX1. These findings provide additional support for a polygenic model of MM and insight into the biological basis of tumour development.

Place, publisher, year, edition, pages
2016. Vol. 7, article id 12050
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-301037DOI: 10.1038/ncomms12050ISI: 000379908200001PubMedID: 27363682OAI: oai:DiVA.org:uu-301037DiVA, id: diva2:953463
Funder
Swedish Foundation for Strategic Research , KF10-0009Marianne and Marcus Wallenberg Foundation, 2010.0112Knut and Alice Wallenberg Foundation, 2012.0193Swedish Research Council, 2012-1753Swedish Society of MedicineAvailable from: 2016-08-17 Created: 2016-08-17 Last updated: 2017-11-28Bibliographically approved

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