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Active dose selection and dose-response modeling for quantitative high-throughput screening (qHTS)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cancer Pharmacology and Computational Medicine.
2016 (English)Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

This master thesis studies the potential benefit of iterative selection of the concentrations

evaluated when building mathematical dose-response curves (and response surfaces when

there are two drugs) using experimental measurements. The reference alternative is to use

a standard two-fold dilution series or ten-fold dilution series measured in replicates. The

standard 4-parameter Hill dose-response model is used as a reference and for simulations.

Models to screen for synergy between two different substances are also developed in this thesis.

Place, publisher, year, edition, pages
2016. , 62 p.
Series
UPTEC X, 16026
National Category
Medical Biotechnology Engineering and Technology
Identifiers
URN: urn:nbn:se:uu:diva-300682OAI: oai:DiVA.org:uu-300682DiVA: diva2:951902
Educational program
Molecular Biotechnology Engineering Programme
Supervisors
Examiners
Available from: 2016-09-05 Created: 2016-08-10 Last updated: 2016-10-24Bibliographically approved

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Type fulltextMimetype application/pdf

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