Active dose selection and dose-response modeling for quantitative high-throughputscreening (qHTS)
Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
This master thesis studies the potential benefit of iterative selection of the concentrations
evaluated when building mathematical dose-response curves (and response surfaces when
there are two drugs) using experimental measurements. The reference alternative is to use
a standard two-fold dilution series or ten-fold dilution series measured in replicates. The
standard 4-parameter Hill dose-response model is used as a reference and for simulations.
Models to screen for synergy between two different substances are also developed in this thesis.
Place, publisher, year, edition, pages
2016. , 62 p.
UPTEC X, 16026
Medical Biotechnology Engineering and Technology
IdentifiersURN: urn:nbn:se:uu:diva-300682OAI: oai:DiVA.org:uu-300682DiVA: diva2:951902
Molecular Biotechnology Engineering Programme
Gustafsson, Mats, Professor
Andersson, Jan, UniversitetslektorLarsson, Rolf, Professor