Risk factors for suicide among patients with schizophrenia: a cohort study focused on cerebrospinal fluid levels of homovanillic acid and 5-hydroxyindoleacetic acid
2016 (English)In: Neuropsychiatric Disease and Treatment, ISSN 1176-6328, E-ISSN 1178-2021, Vol. 12, 1711-1714 p.Article in journal (Refereed) PublishedText
Background: The objective of this study was to investigate the association between 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA) in cerebrospinal fluid (CSF), bullying, and later suicide among patients with schizophrenia. Methods: Ninety-nine patients with schizophrenia were included. Correlations of clinical factors, 5-HIAA and HVA, and later suicide were investigated. Results: Twelve patients committed suicide (12%) during a 28-year follow-up period. Later suicide was correlated to bullying in childhood (P=0.02) and a lower quotient of HVA/5-HIAA in CSF (P<0.05). Conclusion: Suicide in schizophrenia is related to childhood exposedness and CSF neurotransmitter levels.
Place, publisher, year, edition, pages
2016. Vol. 12, 1711-1714 p.
psychosis, risk factors, bullying, HVA, 5-HIAA, CSF
IdentifiersURN: urn:nbn:se:uu:diva-300101DOI: 10.2147/NDT.S107178ISI: 000379339400001OAI: oai:DiVA.org:uu-300101DiVA: diva2:950816