Change search
ReferencesLink to record
Permanent link

Direct link
Physical activity and risk of Amyotrophic Lateral Sclerosis in a prospective cohort study
Show others and affiliations
2016 (English)In: European Journal of Epidemiology, ISSN 0393-2990, E-ISSN 1573-7284, Vol. 31, no 3, 255-266 p.Article in journal (Refereed) PublishedText
Abstract [en]

Previous case-control studies have suggested a possible increased risk of Amyotrophic Lateral Sclerosis (ALS) with physical activity (PA), but this association has never been studied in prospective cohort studies. We therefore assessed the association between PA and risk of death from ALS in the European Prospective Investigation into Cancer and Nutrition. A total of 472,100 individuals were included in the analysis, yielding 219 ALS deaths. At recruitment, information on PA was collected through standardised questionnaires. Total PA was expressed by the Cambridge Physical Activity Index (CPAI) and analysed in relation to ALS mortality, using Cox hazard models. Interactions with age, sex, and anthropometric measures were assessed. Total PA was weakly inversely associated with ALS mortality with a borderline statistically significant trend across categories (p = 0.042), with those physically active being 33 % less likely to die from ALS compared to those inactive: HR = 0.67 (95 % CI 0.42-1.06). Anthropometric measures, sex, and age did not modify the association with CPAI. The present study shows a slightly decreased-not increased like in case-control studies-risk of dying from ALS in those with high levels of total PA at enrolment. This association does not appear confounded by age, gender, anthropometry, smoking, and education. Ours was the first prospective cohort study on ALS and physical activity.

Place, publisher, year, edition, pages
2016. Vol. 31, no 3, 255-266 p.
Keyword [en]
Amyotrophic Lateral Sclerosis, Physical activity, Cohort study, EPIC study, Vigorous physical activity, BMI
National Category
Neurosciences Public Health, Global Health, Social Medicine and Epidemiology
URN: urn:nbn:se:umu:diva-120653DOI: 10.1007/s10654-016-0119-9ISI: 000373642000005PubMedID: 26968841OAI: diva2:950615
Available from: 2016-08-01 Created: 2016-05-18 Last updated: 2016-08-01Bibliographically approved

Open Access in DiVA

fulltext(730 kB)16 downloads
File information
File name FULLTEXT01.pdfFile size 730 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Andersen, Peter M.Wennberg, Patrik
By organisation
Department of Pharmacology and Clinical NeuroscienceDepartment of Public Health and Clinical Medicine
In the same journal
European Journal of Epidemiology
NeurosciencesPublic Health, Global Health, Social Medicine and Epidemiology

Search outside of DiVA

GoogleGoogle Scholar
Total: 16 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 47 hits
ReferencesLink to record
Permanent link

Direct link