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Implementing a domain-specific language for model-based drug development
Leiden Inst Adv Comp Sci, Niels Bohrweg 1, NL-2333 CA Leiden, Netherlands..
Eight Pillars Ltd, Edinburgh, Midlothian, Scotland..
Pfizer Ltd, Global Clin Pharmacol, Sandwich CT13 9NJ, Kent, England..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
2015 (English)In: 6Th International Conference On Emerging Ubiquitous Systems And Pervasive Networks (EUSPN 2015)/The 5Th International Conference On Current And Future Trends Of Information And Communication Technologies In Healthcare (ICTH-2015), 2015, 308-316 p.Conference paper (Refereed)Text
Abstract [en]

In this paper, we present the implementation of a novel domain-specific language (DSL) for pharmacometric modeling called the Modelling Description Language (MDL). MDL is a modular, declarative language with block structures that allows users to abstract data, processes and mathematical models from auxiliary code, and hence, improves model readability, reusability and opportunities for collaborative research. The main aim of this DSL is interoperability between core software tools used in pharmacometrics. We describe the MDL-IDE, an integrated development environment for MDL, which assists users in writing MDL code. The paper focuses on language constructs and design decisions, briefly explains how models are validated and converted to a machine-readable format for processing by existing model simulation and estimation software tools.

Place, publisher, year, edition, pages
2015. 308-316 p.
, Procedia Computer Science, ISSN 1877-0509 ; 63
Keyword [en]
Model-based drug development, pharmacokinetics, domain-specific language, modeling, simulation
National Category
Family Medicine Human Computer Interaction
URN: urn:nbn:se:uu:diva-299161DOI: 10.1016/j.procs.2015.08.348ISI: 000373842900041OAI: diva2:949025
6th International Conference on Emerging Ubiquitous Systems and Pervasive Networks (EUSPN) / 5th International Conference on Current and Future Trends of Information and Communication Technologies in Healthcare (ICTH), SEP 27-30, 2015, Berlin, GERMANY
Available from: 2016-07-15 Created: 2016-07-15 Last updated: 2016-07-15Bibliographically approved

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