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G-Protein-Coupled Lysophosphatidic Acid Receptors and Their Regulation of AKT Signaling
Univ Punjab, Inst Biochem & Biotechnol, Lahore 54590, Pakistan..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
2016 (English)In: International Journal of Molecular Sciences, ISSN 1422-0067, E-ISSN 1422-0067, Vol. 17, no 2Article, review/survey (Refereed) PublishedText
Abstract [en]

A hallmark of G-protein-coupled receptors (GPCRs) is their ability to recognize and respond to chemically diverse ligands. Lysophospholipids constitute a relatively recent addition to these ligands and carry out their biological functions by activating G-proteins coupled to a large family of cell-surface receptors. This review aims to highlight salient features of cell signaling by one class of these receptors, known as lysophosphatidic acid (LPA) receptors, in the context of phosphatidylinositol 3-kinase (PI3K)-AKT pathway activation. LPA moieties efficiently activate AKT phosphorylation and activation in a multitude of cell types. The interplay between LPA, its receptors, the associated Gi/o subunits, PI3K and AKT contributes to the regulation of cell survival, migration, proliferation and confers chemotherapy-resistance in certain cancers. However, detailed information on the regulation of PI3K-AKT signals induced by LPA receptors is missing from the literature. Here, some urgent issues for investigation are highlighted.

Place, publisher, year, edition, pages
2016. Vol. 17, no 2
Keyword [en]
G-protein coupled receptors (GPCR), lysophosphatidic acid (LPA), PI3K, AKT
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
URN: urn:nbn:se:uu:diva-298961DOI: 10.3390/ijms17020215ISI: 000371830800097OAI: oai:DiVA.org:uu-298961DiVA: diva2:948668
Funder
Swedish Cancer Society
Available from: 2016-07-13 Created: 2016-07-12 Last updated: 2016-07-13Bibliographically approved

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Huang, YingJohansson, Staffan
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