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Health-related quality of life in hypertrophic cardiomyopathy patients with implantable defibrillators
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Research and Development, Gävleborg. Karolinska Inst, Karolinska Univ Hosp Solna, Dept Med, Cardiol Res Unit, SE-17176 Stockholm, Sweden..
Umea Univ, Dept Publ Hlth & Clin Med, SE-90187 Umea, Sweden..
Karolinska Inst, Karolinska Univ Hosp Solna, Dept Med, Cardiol Res Unit, SE-17176 Stockholm, Sweden..
Univ Orebro, Univ Hlth Care Res Ctr, Fac Med & Hlth, SE-70182 Orebro, Sweden..
2016 (English)In: Health and Quality of Life Outcomes, ISSN 1477-7525, E-ISSN 1477-7525, Vol. 14, 62Article in journal (Refereed) Published
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Abstract [en]

Background: Health-related quality of life (HRQL) in hypertrophic cardiomyopathy (HCM) patients with implantable cardioverter-defibrillators (ICDs) is largely unknown. The aim was to assess HRQL, including comparisons between groups, using the questionnaire SF-36, and compare it to a Swedish age-and sex-matched population. Methods and Results: Validated data on adult HCM patients with ICDs were used. The SF-36 response rate was 82.5 % and 245 patients (mean age 55.9 years, 70.2 % men) were analyzed using the Mann-Whitney U-test, t-test, Spearman correlation and effect size calculations. In all SF-36 domains the patients' score was lower (p-value of <0.0001) than norms except for bodily pain. The general health domain showed the highest effect size (0.77) and the impact was more pronounced in the SF-36 physical component summary score (0.62) than the mental component summary score (0.46). Older age was correlated with lower scores on the physical component and higher scores on the mental component. Atrial fibrillation and/or systolic heart failure were associated with worse physical health. HRQL was similar in primary vs secondary prevention cases. Inappropriate ICD shock was associated with worse mental health while appropriate therapy trended toward better mental health. Conclusion: HCM patients with ICDs suffer from poor HRQL regardless of age, sex, or primary vs secondary prevention indication. Atrial fibrillation and systolic heart failure are determinants of poor physical health. Inappropriate shocks, but not appropriate therapies, are associated with poorer mental health.

Place, publisher, year, edition, pages
2016. Vol. 14, 62
Keyword [en]
Adult, Hypertrophic cardiomyopathy, Implantable cardioverter-defibrillator, Quality of life, SF-36
National Category
Nursing Health Care Service and Management, Health Policy and Services and Health Economy
Identifiers
URN: urn:nbn:se:uu:diva-297915DOI: 10.1186/s12955-016-0467-xISI: 000374526800001PubMedID: 27079917OAI: oai:DiVA.org:uu-297915DiVA: diva2:944237
Available from: 2016-06-29 Created: 2016-06-28 Last updated: 2017-11-28Bibliographically approved

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