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A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs
Univ Cambridge, WT MRC Inst Metab Sci, Metab Res Labs, Cambridge CB2 0QQ, England..
Univ Cambridge, WT MRC Inst Metab Sci, Metab Res Labs, Cambridge CB2 0QQ, England..
Univ Cambridge, WT MRC Inst Metab Sci, Metab Res Labs, Cambridge CB2 0QQ, England..
Univ Cambridge, WT MRC Inst Metab Sci, Metab Res Labs, Cambridge CB2 0QQ, England..
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2016 (English)In: Cell Metabolism, ISSN 1550-4131, E-ISSN 1932-7420, Vol. 23, no 5, 893-900 p.Article in journal (Refereed) Published
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Abstract [en]

Sequencing of candidate genes for obesity in Labrador retriever dogs identified a 14 bp deletion in pro-opiomelanocortin (POMC) with an allele frequency of 12%. The deletion disrupts the b-MSH and beta-endorphin coding sequences and is associated with body weight (per allele effect of 0.33 SD), adiposity, and greater food motivation. Among other dog breeds, the deletion was only found in the closely related flat-coat retriever (FCR), where it is similarly associated with body weight and food motivation. The mutation is significantly more common in Labrador retrievers selected to become assistance dogs than pets. In conclusion, the deletion in POMC is a significant modifier of weight and appetite in Labrador retrievers and FCRs and may influence other behavioral traits.

Place, publisher, year, edition, pages
2016. Vol. 23, no 5, 893-900 p.
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Endocrinology and Diabetes Cell and Molecular Biology
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URN: urn:nbn:se:uu:diva-297789DOI: 10.1016/j.cmet.2016.04.012ISI: 000375550700019PubMedID: 27157046OAI: oai:DiVA.org:uu-297789DiVA: diva2:943567
Funder
Wellcome trust, 095515/Z/11/ZWellcome trust, 100574/Z/12/Z
Available from: 2016-06-28 Created: 2016-06-28 Last updated: 2017-11-28Bibliographically approved

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Arendt, Maja L.Lindblad-Toh, Kerstin
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