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Biomarkers of lsystemic inflammation in farmers with musculoskeletal disorders: a plasma proteomic study
Linkoping Univ, Div Community Med, Dept Med & Hlth Sci, Fac Hlth Sci, SE-58185 Linkoping, Sweden.;Anaesthet Operat & Specialty Surg Ctr, Pain & Rehabil Ctr, SE-58185 Linkoping, Sweden.;Linkoping Univ, Div Neuro & Inflammat Sci, Dept Clin & Expt Med, Occupat & Environm Med Ctr,Heart & Med Ctr, SE-58185 Linkoping, Sweden..
Linkoping Univ, Div Community Med, Dept Med & Hlth Sci, Fac Hlth Sci, SE-58185 Linkoping, Sweden.;Anaesthet Operat & Specialty Surg Ctr, Pain & Rehabil Ctr, SE-58185 Linkoping, Sweden..
Dept Res & Dev, Region Kronoberg, Vaxjo, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Caring Sciences.
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2016 (English)In: BMC Musculoskeletal Disorders, ISSN 1471-2474, E-ISSN 1471-2474, Vol. 17, 206Article in journal (Refereed) PublishedText
Abstract [en]

Background: Farmers have an increased risk for musculoskeletal disorders (MSD) such as osteoarthritis of the hip, low back pain, and neck and upper limb complaints. The underlying mechanisms are not fully understood. Workrelated exposures and inflammatory responses might be involved. Our objective was to identify plasma proteins that differentiated farmers with MSD from rural referents. Methods: Plasma samples from 13 farmers with MSD and rural referents were included in the investigation. Gel based proteomics was used for protein analysis and proteins that differed significantly between the groups were identified by mass spectrometry. Results: In total, 15 proteins differed significantly between the groups. The levels of leucine-rich alpha-2-glycoprotein, haptoglobin, complement factor B, serotransferrin, one isoform of kininogen, one isoform of alpha-1-antitrypsin, and two isoforms of hemopexin were higher in farmers with MSD than in referents. On the other hand, the levels of alpha-2-HS-glycoprotein, alpha-1B-glycoprotein, vitamin D-binding protein, apolipoprotein A1, antithrombin, one isoform of kininogen, and one isoform of alpha-1-antitrypsin were lower in farmers than in referents. Many of the identified proteins are known to be involved in inflammation. Conclusions: Farmers with MSD had altered plasma levels of protein biomarkers compared to the referents, indicating that farmers with MSD may be subject to a more systemic inflammation. It is possible that the identified differences of proteins may give clues to the biochemical changes occurring during the development and progression of MSD in farmers, and that one or several of these protein biomarkers might eventually be used to identify and prevent work-related MSD.

Place, publisher, year, edition, pages
2016. Vol. 17, 206
Keyword [en]
Musculoskeletal disorder, Farmers, Proteomic, Systemic inflammation, Occupational medicine
National Category
Rheumatology and Autoimmunity Orthopedics
URN: urn:nbn:se:uu:diva-297788DOI: 10.1186/s12891-016-1059-yISI: 000375761500001PubMedID: 27160764OAI: diva2:943559
Swedish Rheumatism Association, R-420491
Available from: 2016-06-28 Created: 2016-06-28 Last updated: 2016-06-28Bibliographically approved

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