Bisphosphonates and the Risk of Fractures: Survival Analysis Using Patient Data from Swedish National Registers
Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesisAlternative title
Bisfosfonater och risken för frakturer : Överlevnadsanalys på patientdata från svenska nationella register (Swedish)
Background Osteoporosis increases the risk of fractures. Bisphosphonates is a group of medications used to treat osteoporosis. Purpose The purpose of this study was to answer the questions: Do bisphosphonates decrease the risk of fractures? Are the effects ofbisphosphonates different depending on a patient’s age or sex? Methods Data were collected for patients in the Swedish National Patient Register who got a fracture between 2006 and 2012 and who were at least fifty years of age. Kaplan-Meier curves and Cox regression were used; both were extended for time-varying covariates and multiple events. Results A patient who had received a bisphosphonate by any given time had an estimated 45.1 % (hazard ratio, .549; 95 % confidence interval, .524-.574) lower rate of fractures than did a patient who would later receive treatment, given that they were the same age when they entered the study. The effect of bisphosphonate treatment did not vary significantly depending on a patient’s age at study entry (p = .866). A patient’s sex had no significant effect on the rate of fractures after adjusting for his/her age at study entry (p = .142). Discussion It is likely that the patients who received a bisphosphonate suffered osteoporosis to a greater extent than did others. If this had not been taken into account the results would have shown that bisphosphonates were associated with an increased rate of fractures.
Place, publisher, year, edition, pages
Probability Theory and Statistics
IdentifiersURN: urn:nbn:se:umu:diva-122689OAI: oai:DiVA.org:umu-122689DiVA: diva2:940571
Peter Nordström, Geriatrik