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Reduced costs of reproduction in females mediate a shift from a male-biased to a female-biased lifespan in humans
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Animal ecology.
Univ Turku, Dept Biol, FIN-20014 Turku, Finland.;Univ Sheffield, Dept Anim & Plant Sci, Sheffield S10 2TN, S Yorkshire, England..
Univ Utah, Huntsman Canc Inst, Dept Family & Consumer Studies & Populat Sci, Salt Lake City, UT 84112 USA..
Univ Utah, Huntsman Canc Inst, Dept Family & Prevent Med & Populat Sci, Salt Lake City, UT 84112 USA..
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2016 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 6, 24672Article in journal (Refereed) PublishedText
Abstract [en]

The causes underlying sex differences in lifespan are strongly debated. While females commonly outlive males in humans, this is generally less pronounced in societies before the demographic transition to low mortality and fertility rates. Life-history theory suggests that reduced reproduction should benefit female lifespan when females pay higher costs of reproduction than males. Using unique longitudinal demographic records on 140,600 reproducing individuals from the Utah Population Database, we demonstrate a shift from male-biased to female-biased adult lifespans in individuals born before versus during the demographic transition. Only women paid a cost of reproduction in terms of shortened post-reproductive lifespan at high parities. Therefore, as fertility decreased over time, female lifespan increased, while male lifespan remained largely stable, supporting the theory that differential costs of reproduction in the two sexes result in the shifting patterns of sex differences in lifespan across human populations. Further, our results have important implications for demographic forecasts in human populations and advance our understanding of lifespan evolution.

Place, publisher, year, edition, pages
2016. Vol. 6, 24672
National Category
Obstetrics, Gynecology and Reproductive Medicine Public Health, Global Health, Social Medicine and Epidemiology
URN: urn:nbn:se:uu:diva-296854DOI: 10.1038/srep24672ISI: 000374254700002PubMedID: 27087670OAI: diva2:940231
Wenner-Gren FoundationsEU, European Research CouncilSwedish Research CouncilNIH (National Institute of Health), AG022095
Available from: 2016-06-20 Created: 2016-06-20 Last updated: 2016-06-20Bibliographically approved

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Bolund, ElisabethMaklakov, Alexei A.
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