Capturing circulating microRNAs in abdominal aortic aneurysm disease
Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
The current study focuses on finding differential expression between circulating microRNAs
in plasma from patients with abdominal aortic aneurysms compared to un-diseased
individuals by using a qPCR-based array. In addition, we evaluated the expression of
deregulated microRNAs in human tissue samples as well as microarray data from two
independent mouse models of aneurysm development. Fifteen miRNAs were found to be
significantly differentially expressed, with four of them surviving multiple testing.
Interestingly all four of them were substantially different in murine aneurysm development.
Place, publisher, year, edition, pages
2016. , 46 p.
UPTEC X, 16016
Abdominal aortic aneurysm, microRNA, microarray, biomarker, experimental mouse model
Bioinformatics and Systems Biology Engineering and Technology
IdentifiersURN: urn:nbn:se:uu:diva-296450OAI: oai:DiVA.org:uu-296450DiVA: diva2:938386
Molecular Biotechnology Engineering Programme
Maegdefessel, Lars, MD, PhD
Andersson, Jan, PhDKällman, Thomas, Bioinformatiker