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Capturing circulating microRNAs in abdominal aortic aneurysm disease
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Biology Education Centre.
2016 (English)Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

The current study focuses on finding differential expression between circulating microRNAs

in plasma from patients with abdominal aortic aneurysms compared to un-diseased

individuals by using a qPCR-based array. In addition, we evaluated the expression of

deregulated microRNAs in human tissue samples as well as microarray data from two

independent mouse models of aneurysm development. Fifteen miRNAs were found to be

significantly differentially expressed, with four of them surviving multiple testing.

Interestingly all four of them were substantially different in murine aneurysm development.

Place, publisher, year, edition, pages
2016. , 46 p.
Series
UPTEC X, 16016
Keyword [en]
Abdominal aortic aneurysm, microRNA, microarray, biomarker, experimental mouse model
National Category
Bioinformatics and Systems Biology Engineering and Technology
Identifiers
URN: urn:nbn:se:uu:diva-296450OAI: oai:DiVA.org:uu-296450DiVA: diva2:938386
Educational program
Molecular Biotechnology Engineering Programme
Supervisors
Examiners
Available from: 2016-06-17 Created: 2016-06-16 Last updated: 2017-11-01Bibliographically approved

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CiteExportLink to record
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Citation style
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