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Modelling of the mechanobiological adaptation to vascular occlusion in the arterial tree
Linköping University, Department of Management and Engineering, Solid Mechanics. (Biomechanics)
2016 (English)Student paper other, 10 credits / 15 HE creditsStudent thesisAlternative title
Modelado de la adaptación mecanobiológica de la oclusión vascular en el árbol arterial (Spanish)
Abstract [en]

It is known that there are many cardiovascular diseases caused by the alterations in the blood vessels, that affect most of the world population. The knowledge of the mechanobiological behavior of blood vessels is used for understanding how cardiovascular diseases could affect the human body. So, by studying the growth and remodeling (G&R) of the arterial tree, it is possible to predict how these diseases will develop and consequently, how they can be treated or even prevented.

The human body naturally tries to find the optimum steady-state by changing either the production of the constituents of the arteries or the flow rate through blood vessels. This effect is the phenomenon that is going to be studied in this thesis and these three main factors have to be taken into account when reproducing the diseases’ effects: the so-called transmural pressure, the blood flow rate, and the biomechanics of the constituents which form the arterial wall. Therefore, through numerical simulations the variation of these factors can be predicted, although always with a reliability supported by experimental data. 

Abstract [es]

Se sabe que hay muchas enfermedades cardiovasculares causadas por alteraciones en los vasos sanguíneos que afectan gran parte de la población mundial. El conocimiento del comportamiento mecanobiológico de los vasos sanguíneos se usa para entender cómo estas enfermedades puede afectar al cuerpo humano. Así, estudiando el crecimiento y desarrollo (G&R) del árbol arterial, es posible predecir cómo estas enfermedades se van a desarrollar y consecuentemente, cómo pueden tratarse o incluso prevenirse.

El cuerpo humano tiende a buscar un estado de equilibrio óptimo de forma natural cambiando o bien la producción de los constituyentes de las arterias o bien el flujo de sangre que atraviesa los vasos sanguíneos. Este efecto es el fenómeno que va a ser estudiado en esta tesis y se ha de tener en cuenta tres factores principales cuando se quiere reproducir los efectos de dichas enfermedades: la presión transmural, el flujo de sangre y la biomecánica de los constituyentes que forman la pared arterial. Luego, a través de simulaciones numéricas la variación de estos factores puede ser predicha, aunque siempre con una veracidad aportada por datos experimentales.

Place, publisher, year, edition, pages
2016. , 53 p.
Keyword [en]
Vascular occlusion, modelling, arteries, arterial tree, growth and remodelling, Murray, cerebrocardiovascular diseases, adaptation, thrombosis, calcification, anemia, polycythemia, isquemia, edema
Keyword [es]
Oclusión vascular, modelado, arterias, árbol arterial, crecimiento y remodelado, Murray, enfermedades cerebrocardiovasculares, adaptación, trombosis, calcificación, anemia, policitemia, isquemia, edema
National Category
Mechanical Engineering
URN: urn:nbn:se:liu:diva-129339ISRN: LIU-IEI-TEK-G--16/00948—SEOAI: diva2:938305
Subject / course
Engineering Mechanics
2016-06-13, Linköping University SE-581 83 LINKÖPING Sweden, Linköping, 09:15 (English)
Vascular occlusion, modelling, arteries, arterial tree, growth and remodelling, Murray, cerebrocardiovascular diseases, adaptation, thrombosis, calcification, anemia, polycythemia, isquemia, edema
Available from: 2016-06-17 Created: 2016-06-16 Last updated: 2016-06-17Bibliographically approved

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