Change search
ReferencesLink to record
Permanent link

Direct link
Biological Membranes in Extreme Conditions: Simulations of Anionic Archaeal Tetraether Lipid Membranes
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences. University of Gdansk, Poland. (CCBG)
Linnaeus University, Faculty of Health and Life Sciences, Department of Biology and Environmental Science.
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences. (CCBG)
2016 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 11, no 5, e0155287Article in journal (Refereed) Published
Abstract [en]

In contrast to the majority of organisms that have cells bound by di-ester phospholipids, archaeal membranes consist of di- and tetraether phospholipids. Originating from organisms that withstand harsh conditions (e.g., low pH and a wide range of temperatures) such membranes have physical properties that make them attractive materials for biological research and biotechnological applications. We developed force-field parameters based on the widely used Generalized Amber Force Field (GAFF) to enable the study of anionic tetraether membranes of the model archaean Sulfolobus acidocaldarius by computer simulations. The simulations reveal that the physical properties of these unique membranes depend on the number of cyclopentane rings included in each lipid unit, and on the size of cations that are used to ensure charge neutrality. This suggests that the biophysical properties of Sulfolobus acidocaldarius cells depend not only on the compositions of their membranes but also on the media in which they grow.

Place, publisher, year, edition, pages
2016. Vol. 11, no 5, e0155287
Keyword [en]
Molecular Dynamics, Sulfolobus acidocaldarius membranes, Lipids, General Amber Force Field
National Category
Theoretical Chemistry Physical Chemistry Biophysics
Research subject
Chemistry, Physical Chemistry
URN: urn:nbn:se:lnu:diva-52482DOI: 10.1371/journal.pone.0155287ISI: 000376587300008ScopusID: 2-s2.0-84969862392OAI: diva2:927862
Available from: 2016-05-13 Created: 2016-05-13 Last updated: 2016-09-07Bibliographically approved

Open Access in DiVA

fulltext(4385 kB)14 downloads
File information
File name FULLTEXT01.pdfFile size 4385 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Other links

Publisher's full textScopus

Search in DiVA

By author/editor
Pineda De Castro, Luis FelipeDopson, MarkFriedman, Ran
By organisation
Department of Chemistry and Biomedical SciencesDepartment of Biology and Environmental Science
In the same journal
Theoretical ChemistryPhysical ChemistryBiophysics

Search outside of DiVA

GoogleGoogle Scholar
Total: 14 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 54 hits
ReferencesLink to record
Permanent link

Direct link