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Association between plasma concentrations of linoleic acid-derived oxylipins and the perceived pain scores in an exploratory study in women with chronic neck pain
Umeå University, Faculty of Science and Technology, Department of Chemistry. Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience.
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience.
Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation. Department of Occupational and Public Health Sciences, Centre for Musculoskeletal Research, University of Gävle, Sweden.
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2016 (English)In: BMC Musculoskeletal Disorders, ISSN 1471-2474, E-ISSN 1471-2474, Vol. 17, 103Article in journal (Refereed) PublishedText
Abstract [en]

Background: Chronic musculoskeletal pain may be associated with changes in the balance of algogenic and anti-nociceptive compounds, and such changes may be visible in plasma samples. We have undertaken an exploratory study to measure the levels of endocannabinoids, related N-acylethanolamines and oxylipins (primarily those derived from linoleic acid) in plasma samples from women with chronic neck pain (NP) and chronic widespread pain (CWP), and to investigate whether the observed levels are associated with the pain experienced by these women.

Methods: Blood samples from 35 women with NP, 15 with CWP and 27 age-matched controls were analysed for the lipids using ultra performance liquid chromatography coupled to tandem mass spectrometry. Current pain (“NRSday”) and the average pain during the last week (“NRSweek”) were rated by the participants using a numerical rating scale.

Results: There were no significant differences in the plasma concentrations of the fifteen lipids investigated between the women with pain and the controls. However, significant correlations were seen for the NP group between the NRSday scores and the plasma concentrations of the linoleic acid derivatives 9- and 13-hydroxy-octadecadienoic acid (Spearman’s rho values 0.51 [P = 0.0016]) and 0.53 [P = 0.0011], respectively).

Conclusions: The data obtained in this exploratory study indicate that although no group differences are seen in plasma lipid concentrations, there is an association between the NRSday scores and the 9- and 13-hydroxy-octadecadienoic acid levels. Whether or not the association reflects a causality (i.e. that the circulating lipids contribute to the perceived pain of the pain participants), requires further investigation.

Place, publisher, year, edition, pages
2016. Vol. 17, 103
Keyword [en]
Musculoskeletal disorders, chronic neck pain, chronic widespread pain, endocannabinoids, N- ylethanolamines, oxylipins, 9-hydroxy-10E, 12Z-octadecadienoic acid, 13-hydroxy-9Z, 11E- tadecadienoic acid
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Other Health Sciences
URN: urn:nbn:se:umu:diva-118393DOI: 10.1186/s12891-016-0951-9ISI: 000370919700001OAI: diva2:920448
Available from: 2016-04-18 Created: 2016-03-18 Last updated: 2016-04-18Bibliographically approved

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Gouveia-Figueira, SandraNording, Malin L.Björklund, MartinFowler, Christopher J.
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Department of ChemistryDepartment of Pharmacology and Clinical NeuroscienceDepartment of Community Medicine and Rehabilitation
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