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Context-Dependent Development of Lymphoid Stroma from Adult CD34(+) Adventitial Progenitors
Tech Univ Denmark, Natl Vet Inst, Sect Immunol & Vaccinol, Bulowsvej 27, DK-1870 Frederiksberg C, Denmark..
Lund Univ, Immunol Sect, BMC D14, S-22184 Lund, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Neuro-Oncology.
Lund Univ, Immunol Sect, BMC D14, S-22184 Lund, Sweden..
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2016 (English)In: Cell reports, ISSN 2211-1247, E-ISSN 2211-1247, Vol. 14, no 10, 2375-2388 p.Article in journal (Refereed) PublishedText
Abstract [en]

Despite the key role of primary and secondary lymphoid organ stroma in immunity, our understanding of the heterogeneity and ontogeny of these cells remains limited. Here, we identify a functionally distinct subset of BP3(-)PDPN(+)PDGFR beta(+)/alpha(+)CD34(+) stromal adventitial cells in both lymph nodes (LNs) and thymus that is located within the vascular niche surrounding PDPN(-)PDGFR beta(+)/alpha(-)Esam-1(+)ITGA7(+) pericytes. CD34(+) adventitial cells developed in late embryonic thymus and in postnatal LNs and in the thymus originated, along with pericytes, from a common anlage-seeding progenitor population. Using lymphoid organ re-aggregate grafts, we demonstrate that adult CD34(+) adventitial cells are capable of differentiating into multiple lymphoid stroma-like subsets including pericyte- ,FRC-, MRC-, and FDC-like cells, the development of which was lymphoid environment-dependent. These findings extend the current understanding of lymphoid mesenchymal cell heterogeneity and highlight a role of the CD34(+) adventitia as a potential ubiquitous source of lymphoid stromal precursors in postnatal tissues.

Place, publisher, year, edition, pages
2016. Vol. 14, no 10, 2375-2388 p.
National Category
Cell and Molecular Biology
URN: urn:nbn:se:uu:diva-283767DOI: 10.1016/j.celrep.2016.02.033ISI: 000371998700010PubMedID: 26947077OAI: diva2:919671
Available from: 2016-04-14 Created: 2016-04-14 Last updated: 2016-04-14Bibliographically approved

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