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Minimally invasive surgical method to detect sound processing in the cochlear apex by optical coherence tomography
Oregon Health and Science University, OR 97239 USA.
Oregon Health and Science University, OR 97239 USA.
Oregon Health and Science University, OR 97239 USA.
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences.
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2016 (English)In: Journal of Biomedical Optics, ISSN 1083-3668, E-ISSN 1560-2281, Vol. 21, no 2, 025003- p.Article in journal (Refereed) PublishedText
Abstract [en]

Sound processing in the inner ear involves separation of the constituent frequencies along the length of the cochlea. Frequencies relevant to human speech (100 to 500 Hz) are processed in the apex region. Among mammals, the guinea pig cochlear apex processes similar frequencies and is thus relevant for the study of speech processing in the cochlea. However, the requirement for extensive surgery has challenged the optical accessibility of this area to investigate cochlear processing of signals without significant intrusion. A simple method is developed to provide optical access to the guinea pig cochlear apex in two directions with minimal surgery. Furthermore, all prior vibration measurements in the guinea pig apex involved opening an observation hole in the otic capsule, which has been questioned on the basis of the resulting changes to cochlear hydrodynamics. Here, this limitation is overcome by measuring the vibrations through the unopened otic capsule using phase-sensitive Fourier domain optical coherence tomography. The optically and surgically advanced method described here lays the foundation to perform minimally invasive investigation of speech-related signal processing in the cochlea. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License.

Place, publisher, year, edition, pages
Keyword [en]
optical coherence tomography; optical interferometry; phase-sensitive Fourier domain optical coherence tomography; cochlear vibration; speech; probe
National Category
Clinical Medicine
URN: urn:nbn:se:liu:diva-126846DOI: 10.1117/1.JBO.21.2.025003ISI: 000371735000006PubMedID: 26836207OAI: diva2:917187

Funding Agencies|NIH NIDCD [R01DC000141]; NIH [R01DC004554, R01DC010201, R01DC011796]; Swedish Research Council [K2014-63X-14061-14-5]; Torsten Soderberg Foundation

Available from: 2016-04-05 Created: 2016-04-05 Last updated: 2016-04-28

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