Change search
ReferencesLink to record
Permanent link

Direct link
Increased Long-Term Cardiovascular Risk After Total Hip Arthroplasty A Nationwide Cohort Study
Karolinska Inst, Danderyd Hosp, Dept Clin Sci, Stockholm, Sweden..
Karolinska Inst, Danderyd Hosp, Dept Clin Sci, Stockholm, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
Registerctr VGR, Swedish Hip Arthroplasty Register, Gothenburg, Sweden.;Univ Gothenburg, Sahlgrenska Acad, Dept Orthoped, Inst Clin Sci, Gothenburg, Sweden.;Massachusetts Gen Hosp, Harris Orthoped Lab, Boston, MA 02114 USA.;Harvard Univ, Sch Med, Boston, MA USA..
Show others and affiliations
2016 (English)In: Medicine (Baltimore, Md.), ISSN 0025-7974, E-ISSN 1536-5964, Vol. 95, no 6, 1-7 p.Article in journal (Refereed) PublishedText
Abstract [en]

Total hip arthroplasty is a common and important treatment for osteoarthritis patients. Long-term cardiovascular effects elicited by osteoarthritis or the implant itself remain unknown. The purpose of the present study was to determine if there is an increased risk of late cardiovascular mortality and morbidity after total hip arthroplasty surgery. A nationwide matched cohort study with data on 91,527 osteoarthritis patients operated on, obtained from the Swedish Hip Arthroplasty Register. A control cohort (n = 270,688) from the general Swedish population was matched 1:3 to each case by sex, age, and residence. Mean follow-up time was 10 years (range, 7-21). The exposure was presence of a hip replacement for more than 5 years. The primary outcome was cardiovascular mortality after 5 years. Secondary outcomes were total mortality and re-admissions due to cardiovascular events. During the first 5 to 9 years, the arthroplasty cohort had a lower cardiovascular mortality risk compared with the control cohort. However, the risk in the arthroplasty cohort increased over time and was higher than in controls after 8.8 years (95% confidence interval [CI] 7.0-10.5). Between 9 and 13 years postoperatively, the hazard ratio was 1.11 (95% CI 1.05-1.17). Arthroplasty patients were also more frequently admitted to hospital for cardiovascular reasons compared with controls, with a rate ratio of 1.08 (95% CI 1.06-1.11). Patients with surgically treated osteoarthritis of the hip have an increased risk of cardiovascular morbidity and mortality many years after the operation when compared with controls.

Place, publisher, year, edition, pages
2016. Vol. 95, no 6, 1-7 p.
National Category
URN: urn:nbn:se:uu:diva-282495DOI: 10.1097/MD.0000000000002662ISI: 000370654700001PubMedID: 26871792OAI: diva2:917088
Åke Wiberg FoundationStockholm County CouncilThe Karolinska Institutet's Research Foundation
Available from: 2016-04-05 Created: 2016-04-05 Last updated: 2016-04-05Bibliographically approved

Open Access in DiVA

fulltext(412 kB)17 downloads
File information
File name FULLTEXT01.pdfFile size 412 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Garland, AnneHailer, Nils P.
By organisation
In the same journal
Medicine (Baltimore, Md.)

Search outside of DiVA

GoogleGoogle Scholar
Total: 17 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 30 hits
ReferencesLink to record
Permanent link

Direct link