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Ribonucleotide reduction - horizontal transfer of a required function spans all three domains
Stockholm University. (Jarone Pinhassi)ORCID iD: 0000-0002-8779-6464
Institut Pasteur, France.
Stockholm University ; Scientific Park of Barcelona, Spain.
Stockholm University.
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2010 (English)In: BMC Evolutionary Biology, ISSN 1471-2148, E-ISSN 1471-2148, Vol. 10, no 1, 383Article in journal (Refereed) Published
Abstract [en]

Ribonucleotide reduction is the only de novo pathway for synthesis of deoxyribonucleotides, the building blocks of DNA. The reaction is catalysed by ribonucleotide reductases (RNRs), an ancient enzyme family comprised of three classes. Each class has distinct operational constraints, and are broadly distributed across organisms from all three domains, though few class I RNRs have been identified in archaeal genomes, and classes II and III likewise appear rare across eukaryotes. In this study, we examine whether this distribution is best explained by presence of all three classes in the Last Universal Common Ancestor (LUCA), or by horizontal gene transfer (HGT) of RNR genes. We also examine to what extent environmental factors may have impacted the distribution of RNR classes. PMID: 21143941

Place, publisher, year, edition, pages
2010. Vol. 10, no 1, 383
National Category
Evolutionary Biology
Research subject
Ecology, Evolutionary Biology
URN: urn:nbn:se:lnu:diva-50966DOI: 10.1186/1471-2148-10-383OAI: diva2:912969
Available from: 2016-03-18 Created: 2016-03-17 Last updated: 2016-04-07Bibliographically approved

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