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RNRdb, a curated database of the universal enzyme family ribonucleotide reductase, reveals a high level of misannotation in sequences deposited to Genbank
Stockholm University. (Jarone Pinhassi)ORCID iD: 0000-0002-8779-6464
Stockholm University ; Scientific Park of Barcelona, Spain.
Stockholm University.
Stockholm University.
2009 (English)In: BMC Genomics, ISSN 1471-2164, E-ISSN 1471-2164, Vol. 10, no 1, 589Article in journal (Refereed) Published
Abstract [en]

Ribonucleotide reductases (RNRs) catalyse the only known de novo pathway for deoxyribonucleotide synthesis, and are therefore essential to DNA-based life. While ribonucleotide reduction has a single evolutionary origin, significant differences between RNRs nevertheless exist, notably in cofactor requirements, subunit composition and allosteric regulation. These differences result in distinct operational constraints (anaerobicity, iron/oxygen dependence and cobalamin dependence), and form the basis for the classification of RNRs into three classes. PMID: 19995434

Place, publisher, year, edition, pages
2009. Vol. 10, no 1, 589
National Category
Evolutionary Biology
Research subject
Ecology, Evolutionary Biology
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URN: urn:nbn:se:lnu:diva-50969DOI: 10.1186/1471-2164-10-589OAI: oai:DiVA.org:lnu-50969DiVA: diva2:912963
Available from: 2016-03-18 Created: 2016-03-17 Last updated: 2017-11-30Bibliographically approved

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