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Environmental Regulation of Yersinia Pathophysiology
Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.
Department of Microbiology, College of Medicine, Howard University, Washington, DC, USA.
Umeå University, Faculty of Science and Technology, Department of Molecular Biology (Faculty of Science and Technology). Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR). (Francis)ORCID iD: 0000-0001-6817-9535
2016 (English)In: Frontiers in Cellular and Infection Microbiology, E-ISSN 2235-2988, Vol. 6, 25Article in journal (Refereed) Published
Abstract [en]

Hallmarks of Yersinia pathogenesis include the ability to form biofilms on surfaces, the ability to establish close contact with eukaryotic target cells and the ability to hijack eukaryotic cell signaling and take over control of strategic cellular processes. Many of these virulence traits are already well-described. However, of equal importance is knowledge of both confined and global regulatory networks that collaborate together to dictate spatial and temporal control of virulence gene expression. This review has the purpose to incorporate historical observations with new discoveries to provide molecular insight into how some of these regulatory mechanisms respond rapidly to environmental flux to govern tight control of virulence gene expression by pathogenic Yersinia.

Place, publisher, year, edition, pages
Frontiers Media S.A , 2016. Vol. 6, 25
Keyword [en]
acidity, temperature, metabolism, RovA, c-di-GMP, cAMP, extracytoplasmic stress, transition metals
National Category
Research subject
URN: urn:nbn:se:umu:diva-117568DOI: 10.3389/fcimb.2016.00025ISI: 000371266600001PubMedID: 26973818OAI: diva2:908292
Swedish Research Council, 2014-2105Swedish Research Council, 2014-6652

Research in the author's own laboratories has been possible through the generous past or present funding support of the National Science Foundation of China (#31170133 and #31570132; SC), National Institute of General Medical Sciences of the National Institutes of Health (#SC2 GM105419; KT), Howard University Medical Alumni Association (KT), Medical Research Foundation of Umeå University (MF), Swedish Research Council (#2014-2105; MF), and Swedish Research Council framework grant—antibiotics and infection (#2014-6652; SC, KT, and MF). Work in the laboratory of MF is performed within the framework of the Umeå Centre for Microbial Research—Linnaeus Program.

Available from: 2016-03-02 Created: 2016-03-02 Last updated: 2016-05-06Bibliographically approved

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