Change search
ReferencesLink to record
Permanent link

Direct link
Glucose and the injured brain-monitored in the neurointensive care unit
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neurosurgery.
2014 (English)In: Frontiers in Neurology, ISSN 1664-2295, E-ISSN 1664-2295, Vol. 5, 91Article in journal (Refereed) Published
Abstract [en]

Brain has a continuous demand for energy that is met by oxidative metabolism of oxygen and glucose. This demand is compromised in the injured brain and if the inadequate supply persists it will lead to permanent tissue damage. Zero values of cerebral glucose have been associated with infarction and poor neurological outcome. Furthermore, hyperglycemia is common in patients with neurological insults and associated with poor outcome. Intensive insulin therapy (IIT) to control blood glucose has been suggested and used in neurointensive care with conflicting results. This review covers the studies reporting on monitoring of cerebral glucose with microdialysis in patients with traumatic brain injury (TBI), subarachnoid hemorrhage (SAH) and ischemic stroke. Studies investigating IIT are also discussed. Available data suggest that low cerebral glucose in patients with TBI and SAH provides valuable information on development of secondary ischemia and has been correlated with worse outcome. There is also indication that the location of the catheter is important for correlation between plasma and brain glucose. In conclusion considering catheter location, monitoring of brain glucose in the neurointensive care not only provides information on imminent secondary ischemia it also reveals the effect of peripheral treatment on the injured brain.

Place, publisher, year, edition, pages
2014. Vol. 5, 91
National Category
Anesthesiology and Intensive Care Neurology Surgery
Research subject
Neurosurgery; Anaesthesiology and Intensive Care; Neurology
URN: urn:nbn:se:uu:diva-276119DOI: 10.3389/fneur.2014.00091PubMedID: 24936196OAI: diva2:907702
Available from: 2016-02-29 Created: 2016-02-09 Last updated: 2016-03-16Bibliographically approved

Open Access in DiVA

fulltext(1239 kB)27 downloads
File information
File name FULLTEXT01.pdfFile size 1239 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Rostami, Elham
By organisation
In the same journal
Frontiers in Neurology
Anesthesiology and Intensive CareNeurologySurgery

Search outside of DiVA

GoogleGoogle Scholar
Total: 27 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 44 hits
ReferencesLink to record
Permanent link

Direct link