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Health-related quality of life at 2, 6 and 12 months after critical illness - lessons learnt from a nationwide follow-up of 4,500 ICU admissions
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Östergötlands Läns Landsting, Anaesthetics, Operations and Specialty Surgery Center, Department of Intensive Care. Linköping University, Faculty of Medicine and Health Sciences. The Swedish Intensive Care Registry, Karlstad, Sweden .
Swedish Intensive Care Registry, Karlstad, Sweden /Clinic of Intensive Care and Perioperative Medicine, Skåne University Hospital (Malmö), Malmö, Sweden.
The Swedish Intensive Care Registry, Karlstad, Sweden .
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Thoracic and Vascular Surgery. The Swedish Intensive Care Registry, Karlstad, Sweden .
2015 (English)Conference paper, Poster (Refereed)
Abstract [en]


The development of intensive care medicine has led to improved survival of patients with complex illnesses and extensive injuries. Survivors are at risk of acquiring physical and functional deficits that may have negative effects on health-related quality of life (HRQoL). The significance of measuring HRQoL has been underlined by critical care researchers since poor HRQoL is associated with an adverse prognosis.


The aim of this work was to examine the development of HRQoL at 2, 6 and 12 months after ICU discharge in a mixed ICU patient population with an ICU-stay > 96 hrs.


We analysed admissions during 2008-2014 to 49 ICUs that submitted follow-up data to the Swedish Intensive Care Registry (SIR, HRQoL was measured using the Short Form 36 (SF36) questionnaire at 2, 6, and 12 months after discharge from ICU. SF36 domains, age, gender, illness severity on admission (SAPS3 probabilities) and length of ICU-stay were analysed for the entire cohort and for important diagnostic groups. SF36 scores were compared to an age- and gender-adjusted Swedish normal population. Differences in SF36 domains were analysed using non-parametric methods. Medians and interquartile ranges are presented.


Complete SF36 responses were analysed for 4453, 4019 and 2515 admissions at 2, 6 and 12 months, respectively. HRQoL at 2 months in patients that subsequently were lost to follow-up was generally similar to those with follow-up, but they were younger, less ill and had shorter ICU-stay. Full longitudinal data with complete SF36 responses were obtained in 1438 patients [Age: 66 yrs. (57-73 yrs.), female gender: 37.2%, SAPS3 prob: 0.36 (0.19-0.55), ICU-stay: 7.0 days (4.9-11.5 days)]. SF36 improved over time in all domains (P < 0.001, Table), although some domains remained stable from 6 to 12 months. Patterns of recovery differed between important diagnostic groups (i.e. sepsis, out-of-hospital cardiac arrest, COPD, ARDS). A large proportion of patients (10-25% depending on SF36 domain) had HRQoL scores at 12 months which was below 2 standard deviations of the age- and gender-adjusted Swedish norm. The cardiac arrest group were among those with best, and the COPD group were among those with worst HRQoL at 12 months.


HRQoL recovered over 12 months in critically ill patients with a prolonged ICU stay. Recovery varied between diagnostic groups and a large proportion of patients had markedly depressed HRQoL. These findings may have important implications for follow-up and care after critical illness.

Place, publisher, year, edition, pages
Springer, 2015. Vol. 3, A408- p.
, Intensive Care Medicine Experimental, ISSN 2197-425X
National Category
Clinical Medicine
URN: urn:nbn:se:liu:diva-125566DOI: 10.1186/2197-425X-3-S1-A408OAI: diva2:907059
ESICM Lives 2015, Berlin Germany, 3-7 October 2015
Available from: 2016-02-26 Created: 2016-02-26 Last updated: 2016-08-19

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Orwelius, LottiWalther, Sten
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Division of Clinical SciencesDepartment of Intensive CareFaculty of Medicine and Health SciencesDivision of Cardiovascular MedicineDepartment of Thoracic and Vascular Surgery
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