Change search
ReferencesLink to record
Permanent link

Direct link
Changes in the anticitrullinated peptide antibody response in relation to therapeutic outcome in early rheumatoid arthritis: results from the SWEFOT trial
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Region Östergötland, Heart and Medicine Center, Department of Rheumatology. Linköping University, Faculty of Medicine and Health Sciences. Karolinska Institute, Sweden.
Helsingborgs Lasarett, Sweden; Skåne University Hospital, Sweden.
Karolinska Institute, Sweden.
Skåne University Hospital, Sweden.
Show others and affiliations
2016 (English)In: Annals of the Rheumatic Diseases, ISSN 0003-4967, E-ISSN 1468-2060, Vol. 75, no 2, 356-361 p.Article in journal (Refereed) PublishedText
Abstract [en]

Objective To determine the relationship between changes in antibody levels towards citrullinated peptides derived from different candidate autoantigens and therapeutic outcome in early rheumatoid arthritis (RA). Methods Baseline and 3-month serum samples from 316 patients with early RA enrolled in the Swedish Farmacotherapy (SWEFOT) trial were analysed for antibodies against cyclic citrullinated peptides (CCP) and citrullinated peptides derived from vimentin (cVim), fibrinogen (cFib) and a-enolase (CEP-1). At 3-month follow-up, methotrexate monotherapy-inadequate responders were randomised to add-on therapy with sulfasalazine and hydroxychloroquine or infliximab. In these patients, anticitrullinated peptide antibodies (ACPA) were also assessed at 12 and 24 months. The proportion of antibody-positive patients and relative changes in antibody levels were compared across ACPA specificities and related to therapeutic response and radiographic progression. Results During the 2-year follow-up, the proportion of patients testing positive declined significantly regarding antibodies to cVim, cFib and CEP-1, while anti-CCP antibody occurrence remained stable over time. Turning anti-cVim antibody negative was most common, and anti-cVim antibody seroreversion during the first three months associated with significantly less 2-year radiographic progression compared with patients who remained positive. Median antibody levels of all tested ACPAs declined uniformly during initial methotrexate therapy and following response to add-on therapy, with no significant relation to treatment regimen or radiographic progression. Conclusions The influence of early antirheumatic therapy on ACPA seroreversions was markedly different across specificities, and early disappearance of anti-cVim antibodies associated with better radiological outcome. Thus, these data suggest that the disappearance of particular ACPA reactivities may be beneficial in early RA.

Place, publisher, year, edition, pages
BMJ PUBLISHING GROUP , 2016. Vol. 75, no 2, 356-361 p.
National Category
Clinical Medicine
URN: urn:nbn:se:liu:diva-125298DOI: 10.1136/annrheumdis-2014-205698ISI: 000368955700006PubMedID: 25550338OAI: diva2:906397

Funding Agencies|EU [FP7-Health-2010-261460, FP7-Health-2013-306029]; County Council of Ostergotland; Reinhold Sund Foundation; Swedish Society of Medicine; Swedish Rheumatism Association; Thelma Zoegas foundation in Helsingborg; Stiftelsen for Rorelsehindrade i Skane; Swedish Research Council; Strategic Foundations of Sweden (SSF)

Available from: 2016-02-24 Created: 2016-02-19 Last updated: 2016-03-16

Open Access in DiVA

fulltext(643 kB)36 downloads
File information
File name FULLTEXT01.pdfFile size 643 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Kastbom, Alf
By organisation
Division of Neuro and Inflammation ScienceDepartment of RheumatologyFaculty of Medicine and Health Sciences
In the same journal
Annals of the Rheumatic Diseases
Clinical Medicine

Search outside of DiVA

GoogleGoogle Scholar
Total: 36 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 937 hits
ReferencesLink to record
Permanent link

Direct link