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New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
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2016 (English)In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 7, 10495Article in journal (Refereed) Published
Abstract [en]

To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.

Place, publisher, year, edition, pages
2016. Vol. 7, 10495
National Category
Medical and Health Sciences Medical Genetics
URN: urn:nbn:se:uu:diva-275672DOI: 10.1038/ncomms10495ISI: 000371012200002PubMedID: 26833246OAI: diva2:900714
AstraZenecaGerman Research Foundation (DFG)German Research Foundation (DFG), SFB992EU, FP7, Seventh Framework ProgrammeEU, European Research Council, ERC-StG-281641Knut and Alice Wallenberg FoundationGlaxoSmithKline (GSK)Novo NordiskThe Royal Swedish Academy of SciencesSwedish Diabetes AssociationSwedish Foundation for Strategic Research Swedish Heart Lung FoundationWellcome trust
Available from: 2016-02-04 Created: 2016-02-04 Last updated: 2016-04-05Bibliographically approved

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Gustafsson, StefanHedman, Åsa KCederholm, TommyMichaëlsson, KarlLind, LarsIngelsson, Erik
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Molecular epidemiologyScience for Life Laboratory, SciLifeLabDepartment of Medical SciencesClinical Nutrition and MetabolismOrthopaedicsCardiovascular epidemiology
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