Polymer/Iron Oxide Nanoparticle Composites-A Straight Forward and Scalable Synthesis Approach
2015 (English)In: International Journal of Molecular Sciences, ISSN 1422-0067, E-ISSN 1422-0067, Vol. 16, no 8, 19752-19768 p.Article in journal (Refereed) PublishedText
Magnetic nanoparticle systems can be divided into single-core nanoparticles (with only one magnetic core per particle) and magnetic multi-core nanoparticles (with several magnetic cores per particle). Here, we report multi-core nanoparticle synthesis based on a controlled precipitation process within a well-defined oil in water emulsion to trap the superparamagnetic iron oxide nanoparticles (SPION) in a range of polymer matrices of choice, such as poly(styrene), poly(lactid acid), poly(methyl methacrylate), and poly(caprolactone). Multi-core particles were obtained within the Z-average size range of 130 to 340 nm. With the aim to combine the fast room temperature magnetic relaxation of small individual cores with high magnetization of the ensemble of SPIONs, we used small (<10 nm) core nanoparticles. The performed synthesis is highly flexible with respect to the choice of polymer and SPION loading and gives rise to multi-core particles with interesting magnetic properties and magnetic resonance imaging (MRI) contrast efficacy.
Place, publisher, year, edition, pages
2015. Vol. 16, no 8, 19752-19768 p.
iron oxide nanoparticle, multi core, single core, nanocomposite, polymer encapsulation
Nano Technology Biochemistry and Molecular Biology Chemical Sciences
IdentifiersURN: urn:nbn:se:uu:diva-274714DOI: 10.3390/ijms160819752ISI: 000366826100161PubMedID: 26307966OAI: oai:DiVA.org:uu-274714DiVA: diva2:899592
FunderEU, FP7, Seventh Framework Programme, 604448