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Recovery of dynamics and function in spiking neural networks with closed-loop control
KTH, School of Computer Science and Communication (CSC), Computational Science and Technology (CST). University of Freiburg, Germany.ORCID iD: 0000-0002-8044-9195
2016 (English)In: PloS Computational Biology, ISSN 1553-734X, E-ISSN 1553-7358, Vol. 12, no 2, e1004720- p.Article in journal (Refereed) Published
Abstract [en]

There is a growing interest in developing novel brain stimulation methods to control disease-related aberrant neural activity and to address basic neuroscience questions. Conventional methods for manipulating brain activity rely on open-loop approaches that usually lead to excessive stimulation and, crucially, do not restore the original computations performed by the network. Thus, they are often accompanied by undesired side-effects. Here, we introduce delayed feedback control (DFC), a conceptually simple but effective method, to control pathological oscillations in spiking neural networks (SNNs). Using mathematical analysis and numerical simulations we show that DFC can restore a wide range of aberrant network dynamics either by suppressing or enhancing synchronous irregular activity. Importantly, DFC, besides steering the system back to a healthy state, also recovers the computations performed by the underlying network. Finally, using our theory we identify the role of single neuron and synapse properties in determining the stability of the closed-loop system.

Place, publisher, year, edition, pages
PLOS , 2016. Vol. 12, no 2, e1004720- p.
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Research subject
Biological Physics
URN: urn:nbn:se:kth:diva-181419DOI: 10.1371/journal.pcbi.1004720ScopusID: 2-s2.0-84959559209OAI: diva2:899449

QC 20160210

Available from: 2016-02-01 Created: 2016-02-01 Last updated: 2016-02-10Bibliographically approved

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Kumar, Arvind
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