Chapter 31 Valvular Interstitial Cells
2016 (English)In: Mitral Valve Mechanics / [ed] Neil B Ingels, Jr and Matts Karlsson, Linköping University Electronic Press, 2016, 31.1-31.1 p.Chapter in book (Other academic)
The stiffening "twitch" of the annular half of the anterior mitral leaflet at the beginning of each beat likely arises from P-wave-stimulated, β-dependent, neurally-insensitive myocytes located in this region. The source of the ubiquitous, β-independent, neurally-sensitive, steady-state stiffness "tone" of the entire anterior leaflet is less clear, but may involve contractile Valvular Interstitial Cells (VICs) bound to leaflet collagen by α2β1 integrins, as discussed by Stephens et al.
Place, publisher, year, edition, pages
Linköping University Electronic Press, 2016. 31.1-31.1 p.
Fluid Mechanics and Acoustics
IdentifiersURN: urn:nbn:se:liu:diva-124250DOI: 10.3384/book.diva-117057ISBN: 978-91-7685-952-0OAI: oai:DiVA.org:liu-124250DiVA: diva2:897144