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Apoptosis, autophagy and unfolded proteinresponse pathways in Arbovirus replicationand pathogenesis
National Microbiology Laboratory, Canada.
Islamic Azad University.
University of Tehran.
University of Manitoba.
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2016 (English)In: Expert Reviews in Molecular Medicine, ISSN 1462-3994, E-ISSN 1462-3994, Vol. 18, no e1, 21- p.Article, review/survey (Refereed) Published
Abstract [en]

Arboviruses are pathogens that widely affect the health of people in different communities around the world. Recently, a few successful approaches toward production of effective vaccines against some of these pathogens have been developed, but treatment and prevention of the resulting diseases remain a major health and research concern. The arbovirus infection and replication processes are complex, and many factors are involved in their regulation. Apoptosis, autophagy and the unfolded protein response (UPR) are three mechanisms that are involved in pathogenesis of many viruses. In this review, we focus on the importance of these pathways in the arbovirus replication and infection processes. We provide a brief introduction on how apoptosis, autophagy and the UPR are initiated and regulated, and then discuss the involvement of these pathways in regulation of arbovirus pathogenesis.

Place, publisher, year, edition, pages
Cambridge University Press, 2016. Vol. 18, no e1, 21- p.
Keyword [en]
apoptosis; cell death, viral infection;
National Category
Microbiology in the medical area
URN: urn:nbn:se:liu:diva-124168DOI: 10.1017/erm.2015.19ISI: 000368708700001PubMedID: 26781343OAI: diva2:896082

Funding agencies: University of Manitoba; Manitoba Medical Service Foundation; Canadian Institutes of Health Research [MT-11630]

Available from: 2016-01-20 Created: 2016-01-20 Last updated: 2016-03-10

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Wiechec, Emilia
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Department of Clinical and Experimental MedicineDepartment of Otorhinolaryngology in LinköpingFaculty of Medicine and Health Sciences
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