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Biomarkers of nutrition and stress in pregnant women with a history of eating disorders in relation to head circumference and neurocognitive function of the offspring
Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden..
Karolinska Inst, Div Psychiat, Dept Clin Neurosci, Stockholm, Sweden.;Univ Gothenburg, Sahlgrenska Acad, Div Psychiat & Neurochem, Dept Neurosci & Physiol, Gothenburg, Sweden..
Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Gastroenterology/Hepatology.
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2015 (English)In: BMC Pregnancy and Childbirth, ISSN 1471-2393, E-ISSN 1471-2393, Vol. 15, 318Article in journal (Refereed) Published
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Abstract [en]

Background: Eating disorders during pregnancy can affect fetal growth and the child's early development, but the underlying mechanisms have not been elucidated. The aim of the present study was to investigate serum biomarkers of nutrition and stress in pregnant women with previous eating disorders compared to controls and in relation to head circumference and early neurocognitive development of the offspring. Methods: In a longitudinal cohort study, pregnant nulliparous non-smoking women with a history of anorexia nervosa (n = 20), bulimia nervosa (n = 17) and controls (n = 59) were followed during pregnancy and their children's growth and neurocognitive development were followed up to five years of age. We investigated maternal serum biomarkers of nutrition and stress (ferritin, cortisol, thyroid-stimulating hormone, free thyroxine, insulin, insulin-like growth factor I (IGF-I) and IGF binding protein 1) in blood samples collected during early pregnancy and compared between groups (ANOVA, LSD post-hoc test). The results were related to previous data on head circumference at birth and neurocognitive development at five years of age of the offspring (Spearman rank correlation or Pearson correlation test). Results: Serum levels of ferritin in the women with previous anorexia nervosa, but not in those with a history of bulimia nervosa, were significantly lower than in the controls (p < 0.01), and correlated strongly to impaired memory function in their children (rs = -0.70, p < 0.001). Maternal serum levels of free thyroxine were similar between groups but correlated positively to reduced head circumference at birth of the children in the bulimia nervosa group (r = 0.48, p < 0.05), and with the same tendency in the anorexia nervosa group (r = 0.42, p = 0.07), but not in the controls (r = 0.006). There were no significant differences in cortisol or the other biomarkers between groups. Conclusions: Low maternal serum ferritin in women with previous anorexia nervosa may be of importance for impaired memory capacity in the offspring at five years of age. Our results also indicate that thyroxin levels in pregnant women with previous eating disorders are positively associated with fetal head growth.

Place, publisher, year, edition, pages
2015. Vol. 15, 318
Keyword [en]
Anorexia nervosa, Bulimia nervosa, Pregnancy, Ferritin, Thyroxine, Head circumference, Neurocognitive development, Offspring
National Category
Obstetrics, Gynecology and Reproductive Medicine Pediatrics
Identifiers
URN: urn:nbn:se:uu:diva-271433DOI: 10.1186/s12884-015-0741-7ISI: 000365451400002PubMedID: 26613953OAI: oai:DiVA.org:uu-271433DiVA: diva2:891957
Funder
Swedish Research Council, 20324Stockholm County CouncilThe Karolinska Institutet's Research Foundation
Available from: 2016-01-08 Created: 2016-01-08 Last updated: 2017-12-01Bibliographically approved

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