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Validity and Responsiveness of At-Home Touch Screen Assessments in Advanced Parkinson's Disease
Dalarna Univ, Sch Technol & Business Studies, Comp Engn, S-79188 Falun, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neurology.
Karolinska Inst, Dept Clin Neurosci, Neurol, S-14186 Huddinge, Sweden..
Karolinska Univ Hosp, Dept Neurol, S-17177 Stockholm, Sweden..
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2015 (English)In: IEEE journal of biomedical and health informatics, ISSN 2168-2194, E-ISSN 2168-2208, Vol. 19, no 6, 1829-1834 p.Article in journal (Refereed) PublishedText
Abstract [en]

The aim of this study was to investigate if a telemetry test battery can be used to measure effects of Parkinson's disease (PD) treatment intervention and disease progression in patients with fluctuations. Sixty-five patients diagnosed with advanced PD were recruited in an open longitudinal 36-month study; 35 treated with levodopa-carbidopa intestinal gel (LCIG) and 30 were candidates for switching from oral PD treatment to LCIG. They utilized a test battery, consisting of self-assessments of symptoms and fine motor tests (tapping and spiral drawings), four times per day in their homes during week-long test periods. The repeated measurements were summarized into an overall test score (OTS) to represent the global condition of the patient during a test period. Clinical assessments included ratings on unified PD rating scale (UPDRS) and 39-item PD questionnaire (PDQ-39) scales. In LCIG-naive patients, the mean OTS compared to baseline was significantly improved from the first test period on LCIG treatment until month 24. In LCIG-non naive patients, there were no significant changes in the mean OTS until month 36. The OTS correlated adequately with total UPDRS (rho = 0.59) and total PDQ-39 (0.59). Responsiveness measured as effect size was 0.696 and 0.536 for OTS and UPDRS, respectively. The trends of the test scores were similar to the trends of clinical rating scores but the dropout rate was high. Correlations betweenOTS and clinical rating scales were adequate indicating that the test battery contains important elements of the information of well-established scales. The responsiveness and reproducibility were better for OTS than for total UPDRS.

Place, publisher, year, edition, pages
2015. Vol. 19, no 6, 1829-1834 p.
Keyword [en]
Home assessment, levodopa infusion, Parkinson's, disease (PD), remote monitoring, telemedicine.
National Category
Medical Biotechnology
URN: urn:nbn:se:uu:diva-269978DOI: 10.1109/JBHI.2015.2468088ISI: 000364857000007PubMedID: 26285227OAI: diva2:885598
Available from: 2015-12-19 Created: 2015-12-19 Last updated: 2015-12-19Bibliographically approved

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