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Elevated concentrations of serum matrix metalloproteinase-2 and -9 and their associations with circulating markers of cardiovascular diseases in chronic arsenic-exposed individuals
University of Rajshahi, Bangladesh / Islamic University, Kushtia-7003, Bangladesh.
University of Rajshahi, Rajshahi-6205, Bangladesh.
Islamic University, Kushtia-7003, Bangladesh.
University of Rajshahi, Rajshahi-6205, Bangladesh.
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2015 (English)In: Environmental health, ISSN 1476-069X, E-ISSN 1476-069X, Vol. 14, no 1, 92Article in journal (Refereed) Published
Abstract [en]

Background: Cardiovascular diseases (CVDs) and cancers are the major causes of chronic arsenic exposure-related morbidity and mortality. Matrix metalloproteinase-2 (MMP-2) and −9 (MMP-9) are deeply involved in the pathogenesis of CVDs and cancers. This study has been designed to evaluate the interactions of arsenic exposure with serum MMP-2 and MMP-9 concentrations especially in relation to the circulating biomarkers of CVDs.

Methods: A total of 373 human subjects, 265 from arsenic-endemic and 108 from non-endemic areas in Bangladesh were recruited for this study. Arsenic concentrations in the specimens were measured by inductively coupled plasma mass spectroscopy (ICP-MS) and serum MMPs were quantified by immunoassay kits.

Results: Serum MMP-2 and MMP-9 concentrations in arsenic-endemic population were significantly (p < 0.001) higher than those in non-endemic population. Both MMPs showed significant positive interactions with drinking water (rs = 0.208, p < 0.001 for MMP-2; rs = 0.163, p <0.01 for MMP-9), hair (rs= 0.163, p < 0.01 for MMP-2; rs = 0.173, p < 0.01 for MMP-9) and nail (rs= 0.160, p < 0.01 for MMP-2; rs = 0.182, p < 0.001 for MMP-9) arsenic of the study subjects. MMP-2 concentrations were 1.02, 1.03 and 1.05 times, and MMP-9 concentrations were 1.03, 1.06 and 1.07 times greater for 1 unit increase in log-transformed water, hair and nail arsenic concentrations, respectively, after adjusting for covariates (age, sex, BMI, smoking habit and hypertension). Furthermore, both MMPs were increased dose-dependently when the study subjects were split into three (≤10, 10.1-50 and > 50 μg/L) groups based on the regulatory upper limit of water arsenic concentration set by WHO and Bangladesh Government. MMPs were also found to be significantly (p < 0.05) associated with each other. Finally, the concentrations of both MMPs were correlated with several circulating markers related to CVDs.

Conclusions: This study showed the significant positive associations and dose–response relationships of arsenic exposure with serum MMP-2 and MMP-9 concentrations. This study also showed the interactions of MMP-2 and MMP-9 concentrations with the circulating markers of CVDs suggesting the MMP-2 and MMP-9 -mediated mechanism of arsenic-induced CVDs.

Place, publisher, year, edition, pages
BioMed Central, 2015. Vol. 14, no 1, 92
Keyword [en]
Arsenic, MMP-2, MMP-9, Cardiovascular diseases, Cancer, Bangladesh
National Category
Biochemistry and Molecular Biology
Research subject
Natural sciences
URN: urn:nbn:se:his:diva-11752DOI: 10.1186/s12940-015-0079-7ISI: 000366085600001PubMedID: 26637202ScopusID: 2-s2.0-84949512940OAI: diva2:881937
Available from: 2015-12-11 Created: 2015-12-11 Last updated: 2016-05-25Bibliographically approved

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