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The impact of comorbid disease history on all-cause and cancer-specific mortality in myeloid leukemia and myeloma - a Swedish population-based study
Karolinska Inst, Inst Environm Med, Div Epidemiol, S-10401 Stockholm, Sweden..
Karolinska Inst, Inst Environm Med, Div Epidemiol, Unit Biostat, S-10401 Stockholm, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology. Karolinska Univ Hosp, Karolinska Inst, Clin Epidemiol Unit, Dept Med, Stockholm, Sweden..
Karolinska Inst, Inst Environm Med, Div Epidemiol, Unit Biostat, S-10401 Stockholm, Sweden..
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2015 (English)In: BMC Cancer, ISSN 1471-2407, E-ISSN 1471-2407, Vol. 15, 850Article in journal (Refereed) Published
Abstract [en]

Background: Comorbidity increases overall mortality in patients diagnosed with hematological malignancies. The impact of comorbidity on cancer-specific mortality, taking competing risks into account, has not been evaluated. Methods: Using the Swedish Cancer Register, we identified patients aged > 18 years with a first diagnosis of acute myeloid leukemia (AML, N = 2,550), chronic myeloid leukemia (CML, N = 1,000) or myeloma (N = 4,584) 2002-2009. Comorbid disease history was assessed through in-and out-patient care as defined in the Charlson comorbidity index. Mortality rate ratios (MRR) were estimated through 2012 using Poisson regression. Probabilities of cancer-specific death were computed using flexible parametric survival models. Results: Comorbidity was associated with increased all-cause as well as cancer-specific mortality (cancer-specific MRR: AML= 1.27, 95 % CI: 1.15-1.40; CML = 1.28, 0.96-1.70; myeloma = 1.17, 1.08-1.28) compared with patients without comorbidity. Disorders associated with higher cancer-specific mortality were renal disease (in patients with AML, CML and myeloma), cerebrovascular conditions, dementia, psychiatric disease (AML, myeloma), liver and rheumatic disease (AML), cardiovascular and pulmonary disease (myeloma). The difference in the probability of cancer-specific death, comparing patients with and without comorbidity, was largest among AML patients < 70 years, whereas in myeloma the difference did not vary by age among the elderly. The probability of cancer-specific death was generally higher than other-cause death even in older age groups, irrespective of comorbidity. Conclusion: Comorbidities associated with organ failure or cognitive function are associated with poorer prognosis in several hematological malignancies, likely due to lower treatment tolerability. The results highlight the need for a better balance between treatment toxicity and efficacy in comorbid and elderly AML, CML and myeloma patients.

Place, publisher, year, edition, pages
2015. Vol. 15, 850
National Category
Cancer and Oncology
URN: urn:nbn:se:uu:diva-268403DOI: 10.1186/s12885-015-1857-xISI: 000364116900001PubMedID: 26537111OAI: diva2:878504
Stockholm County Council, 20140204The Karolinska Institutet's Research Foundation
Available from: 2015-12-09 Created: 2015-12-04 Last updated: 2015-12-09Bibliographically approved

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