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Common variants in the ARC gene are not associated withcognitive abilities
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2015 (English)In: Brain and Behavior, ISSN 2162-3279, E-ISSN 2162-3279, Vol. 5, no 10, e00376Article in journal (Refereed) Published
Abstract [en]

Introduction: The Activity-Regulated Cytoskeleton-associated (ARC) gene encodes a protein that is critical for the consolidation of synaptic plasticity and long-term memory formation. Given ARC's key role in synaptic plasticity, we hypothesized that genetic variations in ARC may contribute to interindividual variability in human cognitive abilities or to attention-deficit hyperactivity disorder (ADHD) susceptibility, where cognitive impairment often accompanies the disorder. Methods: We tested whether ARC variants are associated with six measures of cognitive functioning in 670 healthy subjects in the Norwegian Cognitive NeuroGenetics (NCNG) by extracting data from its Genome-Wide Association Study (GWAS). In addition, the Swedish Betula sample of 1800 healthy subjects who underwent similar cognitive testing was also tested for association with 19 tag SNPs. Results: No ARC variants show association at the study-wide level, but several markers show a trend toward association with human cognitive functions. We also tested for association between ARCSNPs and ADHD in a Norwegian sample of cases and controls, but found no significant associations. Conclusion: This study suggests that common genetic variants located in ARC do not account for variance in human cognitive abilities, though small effects cannot be ruled out.

Place, publisher, year, edition, pages
John Wiley & Sons, 2015. Vol. 5, no 10, e00376
Keyword [en]
Activity-regulated cytoskeleton-associated protein, cognition, genetics, memory, single-nucleotide polymorphism, synaptic plasticity
URN: urn:nbn:se:umu:diva-111487DOI: 10.1002/brb3.376ISI: 000363423500007PubMedID: 26516611OAI: diva2:878491
Available from: 2015-12-09 Created: 2015-11-13 Last updated: 2015-12-09Bibliographically approved

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Nilsson, Lars-Göran
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Umeå Centre for Functional Brain Imaging (UFBI)
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