Change search
ReferencesLink to record
Permanent link

Direct link
RNA-Seq of Tumor-Educated Platelets Enables Blood-Based Pan-Cancer, Multiclass, and Molecular Pathway Cancer Diagnostics
Show others and affiliations
2015 (English)In: Cancer Cell, ISSN 1535-6108, E-ISSN 1878-3686, Vol. 28, no 5, 666-676 p.Article in journal (Refereed) Published
Abstract [en]

Tumor-educated blood platelets (TEPs) are implicated as central players in the systemic and local responses to tumor growth, thereby altering their RNA profile. We determined the diagnostic potential of TEPs by mRNA sequencing of 283 platelet samples. We distinguished 228 patients with localized and metastasized tumors from 55 healthy individuals with 96% accuracy. Across six different tumor types, the location of the primary tumor was correctly identified with 71% accuracy. Also, MET or HER2-positive, and mutant KRAS, EGFR, or PIK3CA tumors were accurately distinguished using surrogate TEP mRNA profiles. Our results indicate that blood platelets provide a valuable platform for pan-cancer, multiclass cancer, and companion diagnostics, possibly enabling clinical advances in blood-based "liquid biopsies".

Place, publisher, year, edition, pages
2015. Vol. 28, no 5, 666-676 p.
National Category
Cancer and Oncology Cell Biology
URN: urn:nbn:se:umu:diva-112248DOI: 10.1016/j.ccell.2015.09.018ISI: 000364609100014PubMedID: 26525104OAI: diva2:878275
Available from: 2015-12-08 Created: 2015-12-04 Last updated: 2015-12-08Bibliographically approved

Open Access in DiVA

fulltext(5674 kB)99 downloads
File information
File name FULLTEXT01.pdfFile size 5674 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Nilsson, R. Jonas A.
By organisation
In the same journal
Cancer Cell
Cancer and OncologyCell Biology

Search outside of DiVA

GoogleGoogle Scholar
Total: 99 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 281 hits
ReferencesLink to record
Permanent link

Direct link