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Clinical course of poststroke epilepsy: a retrospective nested case-control study
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neurology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neurology. Uppsala Univ, Dept Neurosci, S-75185 Uppsala, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neurology. Uppsala Univ, Dept Neurosci, S-75185 Uppsala, Sweden..
Uppsala Univ, Dept Neurosci, S-75185 Uppsala, Sweden..
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2015 (English)In: Brain and Behavior, ISSN 2162-3279, E-ISSN 2162-3279, Vol. 5, no 9, e00366Article in journal (Refereed) Published
Abstract [en]

Introduction: Recently, several epidemiological studies have demonstrated that epilepsy develops after approximately 10% of all cerebrovascular lesions. With an aging population, poststroke epilepsy is likely to be of increasing relevance to neurologists and more knowledge on the condition is needed. Patients with poststroke epilepsy are likely to differ from other epilepsy patient populations regarding age, side-effect tolerability, comorbidities, and life expectancy, all of which are important aspects when counselling newly diagnosed patients to make informed treatment decisions. Method: We have here performed a nested case-control study on 36 patients with poststroke epilepsy and 55 controls that suffered stroke but did not develop epilepsy. The average follow-up time was between 3 and 4 years. Results: In our material, two-thirds of patients achieved seizure freedom and 25% experienced a prolonged seizure (status epilepticus) during the follow-up period. Cases consumed more health care following their stroke, but did not suffer more traumatic injuries. Interestingly, the mortality among cases and controls did not differ significantly. This observation needs to be confirmed in larger prospective studies, but indicate that poststroke epilepsy might not infer additional mortality in this patient group with considerable comorbidities. Conclusions: The observations presented can be of value in the counselling of patients, reducing the psychosocial impact of the diagnosis, and planning of future research on poststroke epilepsy.

Place, publisher, year, edition, pages
2015. Vol. 5, no 9, e00366
Keyword [en]
Cerebrovascular diseases, epilepsy, treatment
National Category
Neurology
Identifiers
URN: urn:nbn:se:uu:diva-267340DOI: 10.1002/brb3.366ISI: 000363423200009PubMedID: 26445704OAI: oai:DiVA.org:uu-267340DiVA: diva2:873614
Funder
Swedish Society of Medicine
Available from: 2015-11-24 Created: 2015-11-20 Last updated: 2017-12-01Bibliographically approved

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