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The evolution of early cellular systems viewed through the lens of biological interactions
University of Canterbury, New Zealand.
Linnaeus University, Faculty of Health and Life Sciences, Department of Biology and Environmental Science. Stockholm University. (Ctr Ecol & Evolut Microbial Model Syst)
Yale University, USA.
2015 (English)In: Frontiers in Microbiology, ISSN 1664-302X, E-ISSN 1664-302X, Vol. 6, 1144Article in journal (Refereed) Published
Abstract [en]

The minimal cell concept represents a pragmatic approach to the question of how few genes are required to run a cell. This is a helpful way to build a parts-list, and has been more successful than attempts to deduce a minimal gene set for life by inferring the gene repertoire of the last universal common ancestor, as few genes trace back to this hypothetical ancestral state. However, the study of minimal cellular systems is the study of biological outliers where, by practical necessity, coevolutionary interactions are minimized or ignored. In this paper, we consider the biological context from which minimal genomes have been removed. For instance, some of the most reduced genomes are from endosymbionts and are the result of coevolutionary interactions with a host; few such organisms are "free-living." As few, if any, biological systems exist in complete isolation, we expect that, as with modern life, early biological systems were part of an ecosystem, replete with organismal interactions. We favor refocusing discussions of the evolution of cellular systems on processes rather than gene counts. We therefore draw a distinction between a pragmatic minimal cell (an interesting engineering problem), a distributed genome (a system resulting from an evolutionary transition involving more than one cell) and the looser coevolutionary interactions that are ubiquitous in ecosystems. Finally, we consider the distributed genome and coevolutionary interactions between genomic entities in the context of early evolution.

Place, publisher, year, edition, pages
2015. Vol. 6, 1144
Keyword [en]
minimal genome, distributed genome, last universal common ancestor, coevolution, evolutionary transitions, communal ancestor, levels of selection
National Category
Microbiology Ecology
Research subject
Ecology, Microbiology
URN: urn:nbn:se:lnu:diva-47380DOI: 10.3389/fmicb.2015.01144ISI: 000363861100001PubMedID: 26539175OAI: diva2:873552
Available from: 2015-11-24 Created: 2015-11-24 Last updated: 2016-05-25Bibliographically approved

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