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The role of the Src Homology-2 domain containing protein B (SHB) in β cells
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.ORCID iD: 0000-0002-5467-9755
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
2015 (English)In: Journal of Molecular Endocrinology, ISSN 0952-5041, E-ISSN 1479-6813, Vol. 56, no 1, R21-R31 p.Article, review/survey (Refereed) Published
Abstract [en]

This review will describe the SH2-domain signaling protein Src Homology-2 domaincontaining protein B (SHB) and its role in various physiological processes relating inparticular to glucose homeostasis andbcell function. SHB operates downstream of severaltyrosine kinase receptors and assembles signaling complexes in response to receptoractivation by interacting with other signaling proteins via its other domains (proline-rich,phosphotyrosine-binding and tyrosine-phosphorylation sites). The subsequent responsesare context-dependent. Absence ofShbin mice has been found to exert effects onhematopoiesis, angiogenesis and glucose metabolism. Specifically, first-phase insulinsecretion in response to glucose was impaired and this effect was related to alteredcharacteristics of focal adhesion kinase activation modulating signaling through Akt, ERK,bcatenin and cAMP. It is believed that SHB plays a role in integrating adaptive responses tovarious stimuli by simultaneously modulating cellular responses in different cell-types, thusplaying a role in maintaining physiological homeostasis

Place, publisher, year, edition, pages
2015. Vol. 56, no 1, R21-R31 p.
National Category
Cell and Molecular Biology Physiology
Identifiers
URN: urn:nbn:se:uu:diva-267362DOI: 10.1530/JME-15-0228ISI: 000378353900002PubMedID: 26489764OAI: oai:DiVA.org:uu-267362DiVA: diva2:872857
Funder
Swedish Diabetes AssociationSwedish Cancer Society
Available from: 2015-11-20 Created: 2015-11-20 Last updated: 2016-11-28Bibliographically approved

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