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Glyconanomaterials for biosensing applications
Department of Chemistry, University of Massachusetts, USA.
KTH, School of Chemical Science and Engineering (CHE), Chemistry, Organic Chemistry.ORCID iD: 0000-0003-2865-2513
KTH, School of Chemical Science and Engineering (CHE), Chemistry, Organic Chemistry.
KTH, School of Chemical Science and Engineering (CHE), Chemistry, Organic Chemistry. Department of Chemistry, University of Massachusetts, USA.ORCID iD: 0000-0003-1121-4007
2016 (English)In: Biosensors & bioelectronics, ISSN 0956-5663, E-ISSN 1873-4235, Vol. 76, no 15, 113-130 p.Article in journal, Letter (Refereed) Published
Abstract [en]

Nanomaterials constitute a class of structures that have unique physiochemical properties and are excellent scaffolds for presenting carbohydrates, important biomolecules that mediate a wide variety of important biological events. The fabrication of carbohydrate-presenting nanomaterials, glyconanomaterials, is of high interest and utility, combining the features of nanoscale objects with biomolecular recognition. The structures can also produce strong multivalent effects, where the nanomaterial scaffold greatly enhances the relatively weak affinities of single carbohydrate ligands to the corresponding receptors, and effectively amplifies the carbohydrate-mediated interactions. Glyconanomaterials are thus an appealing platform for biosensing applications. In this review, we discuss the chemistry for conjugation of carbohydrates to nanomaterials, summarize strategies, and tabulate examples of applying glyconanomaterials in in vitro and in vivo sensing applications of proteins, microbes, and cells. The limitations and future perspectives of these emerging glyconanomaterials sensing systems are furthermore discussed.

Place, publisher, year, edition, pages
Elsevier, 2016. Vol. 76, no 15, 113-130 p.
Keyword [en]
Glyconanomaterials, sensing
National Category
Bio Materials Biochemicals
Research subject
Biotechnology; Chemistry
Identifiers
URN: urn:nbn:se:kth:diva-177284DOI: 10.1016/j.bios.2015.07.031ISI: 000364895000011PubMedID: 26212205Scopus ID: 2-s2.0-84959469945OAI: oai:DiVA.org:kth-177284DiVA: diva2:872099
Note

QC 20150715

Available from: 2015-11-17 Created: 2015-11-17 Last updated: 2017-12-01Bibliographically approved

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Neranon, Kitjanit

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