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Membrane vesicle-mediated release of bacterial RNA
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS).
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS).ORCID iD: 0000-0003-3492-3287
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS).
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS).
2015 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 5, 15329Article in journal (Refereed) Published
Abstract [en]

Many Gram-negative bacterial species release outer membrane vesicles (OMVs) that interact with the host by delivering virulence factors. Here, we report for the first time that RNA is among the wide variety of bacterial components that are associated with OMVs. To characterize the RNA profiles of bacterial OMVs, we performed RNA deep sequencing analysis using OMV samples isolated from a wild type Vibrio cholerae O1 El Tor strain. The results showed that RNAs originating from intergenic regions were the most abundant. Our findings reveal a hitherto unrecognised feature of OMVs mimicking eukaryotic exosomes and highlight a need to evaluate the potential role of RNA-containing bacterial membrane vesicles in bacteria-host interactions.

Place, publisher, year, edition, pages
Nature Publishing Group, 2015. Vol. 5, 15329
National Category
Microbiology in the medical area
Identifiers
URN: urn:nbn:se:umu:diva-111144DOI: 10.1038/srep15329ISI: 000363031300001PubMedID: 26483327OAI: oai:DiVA.org:umu-111144DiVA: diva2:868978
Available from: 2015-11-12 Created: 2015-11-06 Last updated: 2017-12-01Bibliographically approved

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Sjöström, Annika ESandblad, LindaUhlin, Bernt EricWai, Sun Nyunt
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