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The Independent Probabilistic Firing of Transcription Factors: A Paradigm for Clonal Variability in the Zebrafish Retina
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Developmental Genetics. Univ Cambridge, Dept Physiol Dev & Neurosci, Cambridge CB2 3DY, England..
Univ Cambridge, Dept Phys, Cambridge CB3 0HE, England..
Univ Cambridge, Dept Physiol Dev & Neurosci, Cambridge CB2 3DY, England..
Univ Cambridge, Dept Phys, Cambridge CB3 0HE, England..
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2015 (English)In: Developmental Cell, ISSN 1534-5807, E-ISSN 1878-1551, Vol. 34, no 5, 532-543 p.Article in journal (Refereed) Published
Abstract [en]

Early retinal progenitor cells (RPCs) in vertebrates produce lineages that vary greatly both in terms of cell number and fate composition, yet how this variability is achieved remains unknown. One possibility is that these RPCs are individually distinct and that each gives rise to a unique lineage. Another is that stochastic mechanisms play upon the determinative machinery of equipotent early RPCs to drive clonal variability. Here we show that a simple model, based on the independent firing of key fate-influencing transcription factors, can quantitatively account for the intrinsic clonal variance in the zebrafish retina and predict the distributions of neuronal cell types in clones where one or more of these fates are made unavailable.

Place, publisher, year, edition, pages
2015. Vol. 34, no 5, 532-543 p.
National Category
Cell Biology
Identifiers
URN: urn:nbn:se:uu:diva-264634DOI: 10.1016/j.devcel.2015.08.011ISI: 000361421300008PubMedID: 26343455OAI: oai:DiVA.org:uu-264634DiVA: diva2:864121
Funder
Wellcome trust, 098357/Z/12/ZWellcome trust, 100329/Z/12/ZSwedish Research Council, 2011-7054
Available from: 2015-10-26 Created: 2015-10-15 Last updated: 2017-12-01Bibliographically approved

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