Thermal stability assessment of antibiotics in moderate temperature and subcriticalwater using a pressurized dynamic flow-through system
2015 (English)In: International Journal of Innovation and Applied Studies, ISSN 2028-9324, Vol. 11, no 4, 872-880 p.Article in journal (Refereed) Published
Thermal degradation of antibiotics has been studied for decades in a broad range of disciplines including food production, agriculture and analytical chemistry. Yet, there is a lack of thermal stability data for many antibiotics. Here we systematically investigated the thermal stability of ten commonly prescribed antibiotics applying a laborsaving automated inhouse pressurized dynamic flow-through system. The design of the system allowed a fast access to a large number of data at medium to subcritical water temperatures, ranging from 50-250 °C. The five ß-lactams cefadroxil, cefuroxime, amoxicillin, penicillin V, and penicillin G showed a high degree of stability with a maximum degradation of less than 30 % at 150 °C. The two quinolones ciprofloxacin and norfloxacin showed a very high thermal stability up to 200 °C, as did trimethoprim andsulfamethoxazole. At 250 °C all antibiotics were either partly of fully removed. The tetracycline doxycycline showed a specific removal pattern probably involving both binding to metal surfaces at lower temperatures as well as degradation at increased temperatures.
Place, publisher, year, edition, pages
2015. Vol. 11, no 4, 872-880 p.
Antibiotics, ß-lactams, cephalosporins, penicillins, fluoroquinolones, trimethoprim, sulfamethoxazole, thermal stability, subcritical water, dynamic system
IdentifiersURN: urn:nbn:se:hkr:diva-14900OAI: oai:DiVA.org:hkr-14900DiVA: diva2:858269