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Brusatol inhibits the response of cultured beta-cells to pro-inflammatory cytokines in vitro
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
2015 (English)In: Biochemical and Biophysical Research Communications - BBRC, ISSN 0006-291X, E-ISSN 1090-2104, Vol. 460, no 3, 868-872 p.Article in journal (Refereed) Published
Abstract [en]

Brusatol is a natural terpenoid that is capable of inducing a variety of biological effects. We presently report that this substance dramatically improves beta-cell survival when exposed to pro-inflammatory cytokines (IL-1 beta and IFN gamma) in vitro. This was observed in insulin producing rat (RIN-5AH), mouse (beta TC6) and human (EndoC-beta H1) beta-cell lines. Brusatol prevented beta-cell oxidative stress in response to cytokines and counteracted induction of iNOS on the protein level. Brusatol, however, block neither the cytokine-induced increase of iNOS mRNA, nor NF-kappa B activation, suggesting that inhibition of iNOS protein expression relies on posttranscriptional mechanism. This indicates that brusatol acts via a novel protective pathway, which may represent a more promising way of improving beta-cell function and survival.

Place, publisher, year, edition, pages
2015. Vol. 460, no 3, 868-872 p.
Keyword [en]
Brusatol, Cytokines, Beta-cells, Oxidative stress, iNOS
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:uu:diva-262449DOI: 10.1016/j.bbrc.2015.03.124ISI: 000359885300061PubMedID: 25824046OAI: oai:DiVA.org:uu-262449DiVA: diva2:853837
Funder
Swedish Diabetes Association
Available from: 2015-09-15 Created: 2015-09-15 Last updated: 2017-12-04Bibliographically approved

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