Change search
ReferencesLink to record
Permanent link

Direct link
Methodology used in studies reporting chronic kidney disease prevalence: a systematic literature review
Show others and affiliations
2015 (English)In: Nephrology, Dialysis and Transplantation, ISSN 0931-0509, E-ISSN 1460-2385, Vol. 30, no S4, 6-16 p.Article, review/survey (Refereed) Published
Abstract [en]

Background. Many publications report the prevalence of chronic kidney disease (CKD) in the general population. Comparisons across studies are hampered as CKD prevalence estimations are influenced by study population characteristics and laboratory methods. Methods. For this systematic review, two researchers independently searched PubMed, MEDLINE and EMBASE to identify all original research articles that were published between 1 January 2003 and 1 November 2014 reporting the prevalence of CKD in the European adult general population. Data on study methodology and reporting of CKD prevalence results were independently extracted by two researchers. Results. We identified 82 eligible publications and included 48 publications of individual studies for the data extraction. There was considerable variation in population sample selection. The majority of studies did not report the sampling frame used, and the response ranged from 10 to 87%. With regard to the assessment of kidney function, 67% used a Jaffe assay, whereas 13% used the enzymatic assay for creatinine determination. Isotope dilution mass spectrometry calibration was used in 29%. The CKD-EPI (52%) and MDRD (75%) equations were most often used to estimate glomerular filtration rate (GFR). CKD was defined as estimated GFR (eGFR) <60 mL/min/1.73 m(2) in 92% of studies. Urinary markers of CKD were assessed in 60% of the studies. CKD prevalence was reported by sex and age strata in 54 and 50% of the studies, respectively. In publications with a primary objective of reporting CKD prevalence, 39% reported a 95% confidence interval. Conclusions. The findings from this systematic review showed considerable variation in methods for sampling the general population and assessment of kidney function across studies reporting CKD prevalence. These results are utilized to provide recommendations to help optimize both the design and the reporting of future CKD prevalence studies, which will enhance comparability of study results.

Place, publisher, year, edition, pages
2015. Vol. 30, no S4, 6-16 p.
Keyword [en]
CKD, CKD-EPI equation, epidemiology, MDRD, systematic review
National Category
Urology and Nephrology
URN: urn:nbn:se:uu:diva-262140DOI: 10.1093/ndt/gfv131ISI: 000359781800002OAI: diva2:852484
Available from: 2015-09-09 Created: 2015-09-09 Last updated: 2015-09-09Bibliographically approved

Open Access in DiVA

fulltext(274 kB)79 downloads
File information
File name FULLTEXT01.pdfFile size 274 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Other links

Publisher's full text

Search in DiVA

By author/editor
Ärnlov, Johan
By organisation
Cardiovascular epidemiology
In the same journal
Nephrology, Dialysis and Transplantation
Urology and Nephrology

Search outside of DiVA

GoogleGoogle Scholar
Total: 79 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 245 hits
ReferencesLink to record
Permanent link

Direct link