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Glucose Homeostasis Variables in Pregnancy versus Maternal and Infant Body Composition
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences.
Karolinska Institute, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences.
2015 (English)In: Nutrients, ISSN 2072-6643, E-ISSN 2072-6643, Vol. 7, no 7, 5615-5627 p.Article in journal (Refereed) Published
Abstract [en]

Intrauterine factors influence infant size and body composition but the mechanisms involved are to a large extent unknown. We studied relationships between the body composition of pregnant women and variables related to their glucose homeostasis, i.e., glucose, HOMA-IR (homeostasis model assessment-insulin resistance), hemoglobin A(1c) and IGFBP-1 (insulin-like growth factor binding protein-1), and related these variables to the body composition of their infants. Body composition of 209 women in gestational week 32 and of their healthy, singleton and full-term one-week-old infants was measured using air displacement plethysmography. Glucose homeostasis variables were assessed in gestational week 32. HOMA-IR was positively related to fat mass index and fat mass (r(2) = 0.32, p less than 0.001) of the women. Maternal glucose and HOMA-IR values were positively (p 0.006) associated, while IGFBP-1was negatively (p = 0.001) associated, with infant fat mass. HOMA-IR was positively associated with fat mass of daughters (p less than 0.001), but not of sons (p = 0.65) (Sex-interaction: p = 0.042). In conclusion, glucose homeostasis variables of pregnant women are related to their own body composition and to that of their infants. The results suggest that a previously identified relationship between fat mass of mothers and daughters is mediated by maternal insulin resistance.

Place, publisher, year, edition, pages
MDPI , 2015. Vol. 7, no 7, 5615-5627 p.
Keyword [en]
body composition; infant; insulin resistance; pregnancy; sex difference
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:liu:diva-121143DOI: 10.3390/nu7075243ISI: 000359349800033PubMedID: 26184296OAI: oai:DiVA.org:liu-121143DiVA: diva2:852262
Note

Funding Agencies|Swedish Research Council [15402]; Swedish Research Council Formas [2008-1332, 2006-614]; Medical Faculty, Linkoping University; County Council of Ostergotland

Available from: 2015-09-08 Created: 2015-09-08 Last updated: 2017-12-04

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