Naringenin improves learning and memory in an Alzheimer's disease rat model: Insights into the underlying mechanisms
2015 (English)In: European Journal of Pharmacology, ISSN 0014-2999, E-ISSN 1879-0712, Vol. 764, 195-201 p.Article in journal (Refereed) Published
Alzheimer's disease (AD) is one of the prevalent neurological disorders of the central nervous system hallmarked by increased beta-amyloid (Aβ) deposition and ensuing learning and memory deficit. In the present study, the beneficial effect of naringenin on improvement of learning and memory was evaluated in an Alzheimer's disease rat model. The Aβ-injected rats showed a lower alternation score in Y-maze task, impairment of retention and recall capability in passive avoidance test, and lower correct choices and higher errors in radial arm maze (RAM) task as compared to sham group in addition to enhanced oxidative stress and apoptosis. Naringenin, but not a combination of naringenin and fulvestrant (an estrogenic receptor antagonist) significantly improved the performance of Aβ-injected rats in passive avoidance and RAM tasks. Naringenin pretreatment of Aβ-injected rats also lowered hippocampal malondialdehyde (MDA) with no significant effect on nitrite and superoxide dismutase (SOD) activity in addition to lowering apoptosis. These results suggest naringenin pretreatment attenuates Aβ-induced impairment of learning and memory through mitigation of lipid peroxidation and apoptosis and its beneficial effect is somewhat mediated via estrogenic pathway.
Place, publisher, year, edition, pages
2015. Vol. 764, 195-201 p.
Naringenin, Alzheimer’s disease, Beta-Amyloid, Learning and Memory, Oxidative stress, Apoptosis
IdentifiersURN: urn:nbn:se:liu:diva-120716DOI: 10.1016/j.ejphar.2015.07.001ISI: 000362987800024PubMedID: 26148826OAI: oai:DiVA.org:liu-120716DiVA: diva2:852134
Funding agencies: Cellular and Molecular Research Center at Iran University of Medical Sciences (Tehran) [2011.37]; Linkoping University (Linkoping, Sweden)2015-09-082015-08-242016-04-12Bibliographically approved