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Role of MKP-2 in crosstalk between MAPK pathways
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Biology Education Centre. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research. (PDGF Signal Transduction)
2015 (English)Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

Abnormalities in Mitogen Activated Protein Kinase (MAPK) signalling may affect the cells essential processes and influence the cell in acquiring traits to favour tumorigenic transformation and the progression of cancer. Deregulation of the MAPK pathways and uncontrolled crosstalk occurring in cancers may be caused by deregulation by MAP-kinase phosphatases (MKPs) that negatively regulates MAPKs by dephosphorylation. In this study, we were interested in the role of MKP-2 in MAPK-signalling pathways. MKP-2 is known to specifically dephosphorylate the MAP kinases Erk1/2, p38 and JNK. In this study, I was to elucidate key events leading to MKP-2 expression and the role of MKP-2 in regulating and balancing MAPK signaling. Also, I was to analyse the possible involvement of p53 in the deregulation of the MAPK pathways and its correlation with MKP-2 expression. In this report, I suggest a model where the Erk1/2 pathway in conjugation with p53 promote MKP-2 expression. I have also discovered a crosstalk between two different MAPK pathways, i.e between Erk1/2 and Erk5.

Place, publisher, year, edition, pages
2015. , 27 p.
, UPTEC X, 15 014
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-261777OAI: diva2:851224
Educational program
Molecular Biotechnology Engineering Programme
Available from: 2015-09-04 Created: 2015-09-03 Last updated: 2015-09-04Bibliographically approved

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